Natural Modulators of Amyloid-Beta Precursor Protein Processing.
Natural Modulators of Amyloid-Beta Precursor Protein Processing.
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DOI：
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发表时间：
2012-09
影响因子：
2.1
通讯作者：
Can Zhang;Rudolph E. Tanzi
中科院分区：
文献类型：
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作者：
Can Zhang;Rudolph E. Tanzi
阿尔茨海默病（AD）是一种毁灭性的神经退行性疾病，是痴呆症的主要原因，目前还没有治愈方法。AD的发病机制被认为主要由Aβ驱动，A β是老年斑的主要成分。Aβ是由淀粉样蛋白-β前体蛋白（APP）通过蛋白水解分泌酶产生的约4 kDa肽。天然产物，特别是那些用于传统中医药（TCM），具有缓解常见临床疾病，包括痴呆症的悠久历史。然而，这些天然产物介导的细胞/分子途径在很大程度上是未知的，直到最近，当疾病的潜在分子机制开始被阐明。在这里，天然产物调节AD的发病机制进行了讨论，特别是通过集中在他们的APP的处理中的作用。
Alzheimer�s disease (AD) is a devastating neurodegenerative disease and the primary cause of dementia, with no cure currently available. The pathogenesis of AD is believed to be primarily driven by Aβ, the principal component of senile plaques. Aβ is an ~4 kDa peptide generated from the amyloid-β precursor protein (APP) through proteolytic secretases. Natural products, particularly those utilized in traditional Chinese medicine (TCM), have a long history alleviating common clinical disorders, including dementia. However, the cell/molecular pathways mediated by these natural products are largely unknown until recently when the underlying molecular mechanisms of the disorders begin to be elucidated. Here, the mechanisms with which natural products modulate the pathogenesis of AD are discussed, in particular, by focusing on their roles in the processing of APP.