ESSENTIAL FATTY-ACID STATUS IN PATIENTS ON LONG-TERM HOME PARENTERAL-NUTRITION
ESSENTIAL FATTY-ACID STATUS IN PATIENTS ON LONG-TERM HOME PARENTERAL-NUTRITION
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DOI：
10.1177/0148607195019004286
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发表时间：
1995-07-01
影响因子：
3.4
通讯作者：
SHAFFER, J
中科院分区：
文献类型：
--
作者：
ABUSHUFA, R;REED, P;SHAFFER, J
背景资料：已知接受全肠外营养的患者存在发生必需脂肪酸缺乏症的风险，表现为一种伴有鳞状皮肤病变的综合征，特征为血浆和红细胞亚油酸浓度低。长期接受家庭肠外营养但可口服饲料的患者的必需脂肪酸状况尚未研究。研究方法：使用等度高效液相色谱法，脂肪酸测定在红细胞和血浆中的25名非禁食患者长期家庭肠外营养和研究结果相比，46名医院门诊病人没有营养支持和5名实验室工作人员。结果：两组的统计学显著差异仅限于红细胞。亚油酸显著降低（25.2 μ mol/10（6）红细胞，p <0.0001），并与三头肌皮褶厚度显著相关（r = 0.52，p = 0.013）。患者的棕榈油酸和油酸高于对照组（10.8 μ mol/10（6）红细胞，p = 0.009; 61.2 μ mol/10（6）红细胞vs 51.7 μ mol/10（6）红细胞，p = 0.003）。结论：尽管静脉注射亚油酸，长期家庭肠外营养的患者红细胞储存的这种必需脂肪酸较低。这似乎与他们的低体脂肪储存有关。我们认为，他们可能使用大量注入的亚油酸作为能量来源，因此有亚临床必需脂肪酸缺乏症的风险。
Background: Patients on total parenteral nutrition are known to be at risk of the development of essential fatty acid deficiency, presenting as a syndrome with scaly skin lesions and characterized by low plasma and erythrocyte linoleic acid concentrations. The essential fatty acid status of patients on long-term home parenteral nutrition who do have access to oral feeds has not been studied. Methods: With the use of an isocratic high-performance liquid chromatography method, fatty acids were measured in the erythrocytes and plasma of 25 nonfasting patients on long-term home parenteral nutrition and the findings compared with those of 46 hospital outpatients not on nutrition support and five laboratory staff. Results: Statistically significant differences in the two groups were limited to the erythrocytes. Linoleic acid was significantly lower (25.2 us 40.7 mu mol/10(6) red blood cells, p < .0001) and showed a significant correlation with triceps skinfold thickness (r = .52, p = .013). Palmitoleic and oleic acids were higher in patients than controls (10.8 us 8.4 mu mol/10(6) red blood cells, p = .009; 61.2 vs 51.7 mol/10(6) red blood cells, p = .003). Conclusions: Despite IV linoleic acid administration, patients on long-term home parenteral nutrition have low erythrocyte stores of this essential fatty acid. This appears to be related to their low body fat stores. We suggest that they may be using much of the infused linoleic acid as an energy source and therefore are at risk of subclinical essential fatty acid deficiency.