Possible association of CCDC62 rs12817488 polymorphism and Parkinson's disease risk in Chinese population: a meta-analysis.
Possible association of CCDC62 rs12817488 polymorphism and Parkinson's disease risk in Chinese population: a meta-analysis.
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CCDC62 rs12817488 多态性与中国人群帕金森病风险的可能关联：一项荟萃分析
DOI：
10.1038/srep23991
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发表时间：
2016-04-01
影响因子：
4.6
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Lu Y;Tan L;Shen N;Peng J;Wang C;Zhu Y;Wang X
有报道称，线圈结构域62 （CCDC62）多态性、rs12817488与帕金森病（PD）之间存在相互矛盾的关联。为了明确rs12817488是否与中国人群的PD风险相关，我们通过检索PubMed和Embase数据库中关于该多态性的文献进行了meta分析。本荟萃分析纳入了三项符合条件的研究，涉及1616例病例和1649例对照。我们的研究结果显示，在所有四种遗传模型中，rs12817488与PD风险之间存在统计学意义上的相关性。性别分层显示，除隐性模型外，两个亚组的结果相似，rs12817488与男性亚组PD无显著相关性。通过敏感性分析发现，隐性模型结果不稳定，隐性模型也存在发表偏倚，提示对隐性模型的汇总结果应谨慎对待。我们的荟萃分析提示rs12817488与中国人群PD风险之间可能存在关联。在不同性别的大样本量研究中进一步验证这种关联是有必要的。
Conflicting results identifying the association between coiled-coil domain containing 62 (CCDC62) polymorphism, rs12817488, and Parkinson’s disease (PD) have been reported. To clarify whether rs12817488 is related to PD risk in Chinese population, we carried out this meta-analysis by searching literature from PubMed and Embase database regarding this polymorphism. Three eligible studies involving 1616 cases and 1649 controls were included in this meta-analysis. Our results showed statistically significant association between rs12817488 and PD risk in all four genetic models. Stratification by gender revealed similar results in both subgroup in these genetic models except for recessive model, in which rs12817488 was not significantly associated with PD in male subgroup. Unstable result was found in recessive model via sensitivity analysis, and publication bias was observed in recessive model as well, indicating that the pooled result from recessive model should be cautiously treated. Our meta-analysis implicates a possible relationship between rs12817488 and PD risk in Chinese population. Further validation of this association in large sample size study with different gender is warranted.