THE MEASURED ELECTRICAL-PROPERTIES OF NORMAL AND MALIGNANT HUMAN TISSUES FROM 50 TO 900 MHZ
THE MEASURED ELECTRICAL-PROPERTIES OF NORMAL AND MALIGNANT HUMAN TISSUES FROM 50 TO 900 MHZ
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DOI：
10.1118/1.597312
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发表时间：
1994-04-01
期刊：
影响因子：
3.8
通讯作者：
JIRTLE, RL
中科院分区：
文献类型：
--
作者：
JOINES, WT;ZHANG, Y;JIRTLE, RL
恶性和正常人体组织的电导率和相对介电常数在50至900 MHz的频率进行了测量。测量是在23至25摄氏度之间进行的，使用连接到平端同轴探针的网络分析仪，该探针压在新鲜切除的组织样本上。恶性组织来源于以下正常组织：膀胱、结肠、肾、肝、肺、淋巴结、乳腺、脾和睾丸。正常组织包括：结肠、肾、肝、肺、乳腺和肌肉。膀胱、淋巴、脾脏和睾丸的正常组织样本不可用。在一般情况下，在所有的频率测试，电导率和相对介电常数是更大的恶性组织比正常组织的相同类型。对于相同类型的组织，从正常到恶性的电特性的差异是最小的肾脏（约6%和4%的介电常数和电导率的频率范围内的平均差异，分别），这些差异是最大的乳腺（约233%和577%的介电常数和电导率的平均差异，分别）。为了说明这些数据在热疗应用中的潜在用途，由宿主正常组织包围的恶性组织（建模为球体）的频率选择性加热从某些组织的测量的电特性计算。
The electrical conductivity and relative permittivity of malignant and normal human tissues were measured at frequencies from 50 to 900 MHz. The measurements were made between 23 and 25 degrees C using a network analyzer connected to a flat-ended coaxial probe that was pressed against the freshly excised tissue samples. The malignant tissues were of the following normal tissue origin: bladder, colon, kidney, liver, lung, lymph nodes, mammary gland, spleen, and testes. The normal tissues included: colon, kidney, liver, lung, mammary gland, and muscle. Normal tissue samples of bladder, lymph, spleen, and testes were not available. In general, at all frequencies tested, both conductivity and relative permittivity were greater in malignant tissue than in normal tissue of the same type. For tissues of the same type, the differences in electrical properties from normal to malignant were the least for kidney (about 6% and 4% average differences over the frequency range in permittivity and conductivity, respectively), and these differences were the greatest for mammary gland (about 233% and 577% average differences in permittivity and conductivity, respectively). To illustrate a potential use of these data in hyperthermia applications, frequency-selective heating of malignant tissue (modeled as a sphere) surrounded by host normal tissue is calculated from the measured electrical properties for certain tissues.