Abdominal obesity and mortality: The Pennington Center Longitudinal Study
Abdominal obesity and mortality: The Pennington Center Longitudinal Study
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DOI：
10.1038/nutd.2012.15
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发表时间：
2012-08-01
影响因子：
6.1
通讯作者：
Bouchard, C.
中科院分区：
文献类型：
--
作者：
Katzmarzyk, P. T.;Mire, E.;Bouchard, C.
本研究的目的是确定内脏脂肪组织(VAT)与全因死亡率之间的关系。样本包括来自彭宁顿中心纵向研究的1089名年龄在18-84岁的白人男性和女性，该研究是在1995年至2008年期间对参与者进行的前瞻性队列评估，并跟踪调查了直到2009年12月31日的死亡率。使用计算机断层扫描测量L4-L5椎体水平的腹部VAT。在平均9.1年的随访期内，共有27人死亡。调整年龄、性别和检查年份后，腹部增值税与死亡率显著相关(危险比(HR)1.46；95%可信区间1.05-2.05)。在将腹部皮下脂肪组织(SAT)、吸烟状况、饮酒和休闲体育活动作为额外的协变量后，相关性更强(HR 1.74；1.17-2.59)。将样本限制在基线水平没有中风、心脏病和癌症的参与者中，会略微降低这种关系的强度(HR 1.62；1.07-2.47)。腹部SAT与死亡率无关，无论是单独或合并增值税和其他协变量。这一结果支持腹部增值税是减肥努力的重要治疗目标的断言。营养与糖尿病(2012年)2，E42；DOI：10.1038/nutd.2012.15；2012年8月27日在线发布
The purpose of this study was to determine the association between visceral adipose tissue (VAT) and all-cause mortality. The sample included 1089 white men and women 18-84 years of age from the Pennington Center Longitudinal Study, a prospective cohort of participants assessed between 1995 and 2008, and followed for mortality until 31 December 2009. Abdominal VAT was measured at the L4-L5 vertebral level using computed tomography. There were 27 deaths during an average of 9.1 years of follow-up. Abdominal VAT was significantly associated with mortality after adjustment for age, sex and year of examination (hazards ratio (HR) 1.46; 95% confidence interval 1.05-2.05). The association was stronger after the inclusion of abdominal subcutaneous adipose tissue (SAT), smoking status, alcohol consumption and leisure-time physical activity as additional covariates (HR 1.74; 1.17-2.59). Limiting the sample to participants who were free of stroke, heart disease and cancer at baseline reduced the strength of the relationship slightly (HR 1.62; 1.07-2.47). Abdominal SAT was not associated with mortality, either alone or in combination with VAT and other covariates. The results support the assertion that abdominal VAT is an important therapeutic target for obesity reduction efforts. Nutrition and Diabetes (2012) 2, e42; doi:10.1038/nutd.2012.15; published online 27 August 2012