Cell membrane-camouflaged nanoparticles for drug delivery.
Cell membrane-camouflaged nanoparticles for drug delivery.
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DOI：
10.1016/j.jconrel.2015.07.019
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发表时间：
2015-12-28
期刊：
影响因子：
--
通讯作者：
Zhang L
中科院分区：
文献类型：
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作者：
Luk BT;Zhang L
纳米颗粒可以优先聚集在作用部位，并有望提高许多药物的治疗指数。虽然纳米载体介导的药物递送的常规方法主要集中在合成方法上，但将合成纳米颗粒与天然生物材料联合收割机组合的工程策略最近获得了很多关注。特别是，细胞膜包裹的纳米颗粒是一类新的仿生纳米颗粒，其联合收割机了细胞膜的独特功能和合成纳米材料的工程多功能性，用于有效递送治疗剂。本文综述了近年来细胞膜包裹纳米粒的研究进展。特别是，我们强调三个领域：（i）通过细胞膜涂层延长体循环，（ii）通过细胞膜涂层的细胞特异性靶向，和（iii）细胞膜涂层用于药物递送的应用。细胞膜包裹的纳米颗粒平台已经成为一种新的递送策略，具有改善治疗多种疾病的疗效的潜力。细胞膜包裹的纳米颗粒是一种新型的药物输送策略。细胞膜涂层方法是多方面的，提供长循环时间，靶向能力和同时多药物递送。
Nanoparticles can preferentially accumulate at sites of action and hold great promise to improve the therapeutic index of many drugs. While conventional methods of nanocarrier-mediated drug delivery have focused on primarily synthetic approaches, engineering strategies that combine synthetic nanoparticles with natural biomaterials have recently gained much attention. In particular, cell membrane-camouflaged nanoparticles are a new class of biomimetic nanoparticles that combine the unique functionalities of cellular membranes and engineering versatility of synthetic nanomaterials for effective delivery of therapeutic agents. Herein, we report on the recent progress on cell membrane-coated nanoparticles for drug delivery. In particular, we highlight three areas: (i) prolonging systemic circulation via cell membrane coating, (ii) cell-specific targeting via cell membrane coating, and (iii) applications of cell membrane coating for drug delivery. The cell membrane-camouflaged nanoparticle platform has emerged as a novel delivery strategy with the potential to improve the therapeutic efficacy for the treatment of a variety of diseases. Cell membrane-coated nanoparticles present a novel emerging strategy for drug delivery. The cell membrane coating approach is multifaceted, offering long circulation times, targeting capabilities, and simultaneous multi-drug delivery.