Conditions associated with leukocytosis in a tertiary care hospital, with particular attention to the role of infection caused by clostridium difficile.
Conditions associated with leukocytosis in a tertiary care hospital, with particular attention to the role of infection caused by clostridium difficile.
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在三级甲等医院治疗与白细胞增多相关的病症，特别要注意艰难梭菌引起的感染的作用。
DOI：
10.1086/340536
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
D. Musher
中科院分区：
文献类型：
--
作者：
Anna Wanahita;Elizabeth A Goldsmith;D. Musher
很少有现代研究列举了与白细胞增多症有关的条件。我们的临床经验已牵连艰难梭菌感染在相当比例的患者白细胞增多。在一项前瞻性观察性研究中，400名WBC计数为>/=15,000个细胞/mm的住院患者(3)，我们记录了207名患者（53%）的>/=1感染。在这207例患者中，97例（47%）发生肺炎，60例（29%）发生尿路感染，34例（16%）发生软组织感染，34例（16%）发生艰难梭菌感染。艰难梭菌感染存在于25%的无血液学恶性肿瘤的WBC计数为30000细胞/mm(3)的患者中。400例患者白细胞增多的其他原因包括生理应激，152例（38%）；药物或药物，42例（11%）；血液病22例（6%）；坏死或炎症22例（6%）。艰难梭菌感染是白细胞增多的主要原因，对于白细胞计数为>/=15,000细胞/mm的患者，即使没有腹泻症状，也应考虑这种诊断(3)。
Few modern studies have enumerated the conditions associated with leukocytosis. Our clinical experience has implicated Clostridium difficile infection in a substantial proportion of patients with leukocytosis. In a prospective, observational study of 400 inpatients with WBC counts of >/=15,000 cells/mm(3), we documented >/=1 infection in 207 patients (53%). Of these 207 patients, 97 (47%) had pneumonia, 60 (29%) had urinary tract infection, 34 (16%) had soft-tissue infection, and 34 (16%) had C. difficile infection. C. difficile infection was present in 25% of patients with WBC counts of >30,000 cells/mm(3) who did not have hematological malignancy. Other causes of leukocytosis in the 400 patients included physiological stress, in 152 patients (38%); medications or drugs, in 42 (11%); hematological disease, in 22 (6%); and necrosis or inflammation, in 22 (6%). C. difficile infection is a prominent cause of leukocytosis and this diagnosis should be considered for patients with WBC counts of >/=15,000 cells/mm(3), even in the absence of diarrheal symptoms.
影响因子：
4.8
作者：
Kyne, L;Hausdorff, JM;Wei, JY
通讯作者：
Wei, JY