Src family kinases as mediators of endothelial permeability: effects on inflammation and metastasis.
Src family kinases as mediators of endothelial permeability: effects on inflammation and metastasis.
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DOI：
10.1007/s00441-008-0682-9
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发表时间：
2009-01
影响因子：
3.6
通讯作者：
Gallick, G. E.
中科院分区：
文献类型：
--
作者：
Kim, M. P.;Park, S. I.;Kopetz, S.;Gallick, G. E.
Src家族激酶（SFK）是一种信号传导酶，长期以来被认为调节重要的细胞过程，如增殖、存活、迁移和转移。近年来，大量的研究工作阐明了SFKs调节血管生物学中正常和病理过程的机制，包括内皮细胞增殖和通透性。此外，当不适当地激活时，SFKs促进病理性炎症过程和肿瘤转移，部分是通过它们对内皮单层通透性的调节作用。在这篇综述中，我们讨论了异常激活的SFKs在炎症状态和肿瘤细胞转移的背景下介导内皮细胞通透性的作用。我们进一步总结了最近的努力，翻译Src特异性抑制剂治疗全身炎症条件和许多实体器官癌症。
Src family kinases (SFKs) are signaling enzymes that have long been recognized to regulate critical cellular processes such as proliferation, survival, migration, and metastasis. Recently, considerable work has elucidated mechanisms by which SFKs regulate normal and pathologic processes in vascular biology, including endothelial cell proliferation and permeability. Further, when inappropriately activated, SFKs promote pathologic inflammatory processes and tumor metastasis, in part through their effects on the regulation of endothelial monolayer permeability. In this review, we discuss the roles of aberrantly activated SFKs in mediating endothelial permeability in the context of inflammatory states and tumor cell metastasis. We further summarize recent efforts to translate Src-specific inhibitors into therapy for systemic inflammatory conditions and numerous solid organ cancers.
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