The use of a tumor antigen TA-4 for the management of squamous cell carcinoma.
The use of a tumor antigen TA-4 for the management of squamous cell carcinoma.
复制标题
使用肿瘤抗原 TA-4 治疗鳞状细胞癌。
DOI：
--
复制
发表时间：
1985
影响因子：
--
通讯作者：
T. Torigoe
中科院分区：
文献类型：
--
作者：
H. Kato;K. Tamai;T. Nagaya;M. Nagai;T. Torigoe
放射免疫法检测鳞状细胞癌的肿瘤抗原TA-4已被用于宫颈癌的治疗。本研究显示了TA-4检测对各种来源的鳞状细胞癌的临床价值。在44.4%的宫颈癌、47.1%的阴道和外阴癌、33.3%的肺癌、42.9%的食管癌和10%的其他来源的癌症中检测到预处理血清TA-4水平。在313例对照病例（包括其他组织学类型的恶性肿瘤或良性疾病）中，1例TA-4水平呈阳性。对鳞状细胞癌患者进行了血清TA-4水平的连续测定，发现TA-4水平变化迅速，有助于监测疾病进展和发现复发性疾病。这些结果表明，TA-4检测将有助于各种来源的鳞状细胞癌的治疗。
A radioimmunoassay for a tumor antigen TA-4 of squamous cell carcinoma has been used for the management of cervical cancer. The present study shows the clinical value of the TA-4 assay for squamous cell carcinoma of various origins. Pretreatment serum TA-4 levels were detectable in 44.4% of cervical cancer, 47.1% of vaginal and vulvar cancer, 33.3% of lung cancer, 42.9% of esophageal cancer, and 10% of cancer of other origins. In 313 control cases, including other histologic types of malignancies or benign diseases, one case showed a positive TA-4 level. Serial determinations of serum TA-4 levels were performed in patients with squamous cell carcinoma, which revealed that changes in TA-4 levels were rapid and were helpful for monitoring the disease progress and for detecting the recurrent disease. These results indicate that the TA-4 assay would be a useful aid for the management of squamous cell carcinoma of various origins.