Can Postural Instability Respond to Galvanic Vestibular Stimulation in Patients with Parkinson's Disease?
Can Postural Instability Respond to Galvanic Vestibular Stimulation in Patients with Parkinson's Disease?
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DOI：
10.14802/jmd.15030
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发表时间：
2016-01
影响因子：
3.9
通讯作者：
Ueno S
中科院分区：
文献类型：
--
作者：
Kataoka H;Okada Y;Kiriyama T;Kita Y;Nakamura J;Morioka S;Shomoto K;Ueno S
前庭电刺激（GVS）激活前庭传入，并且前庭输入的这些变化对受试者的姿势或站立平衡产生强烈影响。在帕金森病（PD）患者中，前庭功能障碍可能导致姿势不稳定和步态障碍。电流强度增加至0.7 mA，并将电流施加于患者20分钟。为了进行假刺激，如所述增加电流强度，然后在10秒的过程中降低至0 mA。在患者仰卧位连续记录患者状态20分钟。5例诊断为PD的患者中有3例伴有姿势不稳定和/或异常轴位，GVS后姿势不稳定性降低。在这些患者中，修订后的统一帕金森病评定量表第3部分第12项的评分降低。姿势不稳定的机制是复杂的，并没有完全理解。在5例患者中，2例患者的姿势不稳定没有改变GVS。尽管如此，在我们的研究中，GVS引起的3例患者的姿势不稳定的变化表明，GVS可能是姿势不稳定的一种治疗选择。
Galvanic vestibular stimulation (GVS) activates the vestibular afferents, and these changes in vestibular input exert a strong influence on the subject’s posture or standing balance. In patients with Parkinson’s disease (PD), vestibular dysfunction might contribute to postural instability and gait disorders. Current intensity was increased to 0.7 mA, and the current was applied to the patients for 20 minutes. To perform a sham stimulation, the current intensity was increased as described and then decreased to 0 mA over the course of 10 seconds. The patient’s status was recorded continuously for 20 minutes with the patient in the supine position. Three out of 5 patients diagnosed with PD with postural instability and/or abnormal axial posture showed a reduction in postural instability after GVS. The score for item 12 of the revised Unified Parkinson’s Disease Rating Scale part 3 was decreased in these patients. The mechanism of postural instability is complex and not completely understood. In 2 out of the 5 patients, postural instability was not changed in response to GVS. Nonetheless, the GVS-induced change in postural instability for 3 patients in our study suggests that GVS might be a therapeutic option for postural instability.