Tumor cell autophagy as an adaptive response mediating resistance to treatments such as antiangiogenic therapy.
Tumor cell autophagy as an adaptive response mediating resistance to treatments such as antiangiogenic therapy.
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DOI：
10.1158/0008-5472.can-12-1076
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发表时间：
2012-09-01
期刊：
影响因子：
11.2
通讯作者：
Aghi MK
中科院分区：
文献类型：
--
作者：
Hu YL;Jahangiri A;Delay M;Aghi MK
自噬是一种溶酶体降解途径，其可以在称为非选择性大自噬的过程中非特异性地螯合包括细胞器的胞质物质，或者可以在称为选择性自噬的过程中靶向指定用于破坏的特定蛋白质聚集体。自噬是一种机制，使肿瘤细胞能够在肿瘤微环境中的压力源中存活，以及由化疗或放疗等治疗引起的损伤。自噬在癌症中的作用的复杂性被以下证据所强调：自噬可以允许癌前细胞逃避促进肿瘤发生的遗传毒性应激和炎症，以及一些肿瘤细胞通过尚未定义的分子机制完全表现出自噬能力的丧失。理解和调节自噬途径的努力对于最大限度地发挥癌症治疗的全部治疗潜力至关重要，目前癌症治疗受到肿瘤细胞自噬作为耐药机制的阻碍。
Autophagy is a lysosomal degradation pathway that can sequester cytosolic material including organelles nonspecifically in a process called nonselective macroautophagy, or can target specific protein aggregates designated for destruction in a process called selective autophagy. Autophagy is one mechanism that enables tumor cells to survive stressors in the tumor microenvironment, as well as injuries caused by treatments like chemotherapy or radiation therapy. The complexity of the role of autophagy in cancer is underscored by evidence that autophagy can allow premalignant cells to escape the genotoxic stress and inflammation that promote tumorigenesis, and by evidence that some tumor cells exhibit loss of autophagy capacity altogether through molecular mechanisms that have not yet been defined. Efforts to understand and modulate the autophagy pathway will be crucial to maximize the full therapeutic potential of cancer therapies which are currently hindered by tumor cell autophagy as a resistance mechanism.