Zika Virus Pathogenesis and Tissue Tropism.
Zika Virus Pathogenesis and Tissue Tropism.
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DOI：
10.1016/j.chom.2017.01.004
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发表时间：
2017-02-08
影响因子：
30.3
通讯作者：
Diamond MS
中科院分区：
文献类型：
--
作者：
Miner JJ;Diamond MS
虽然寨卡病毒(ZIKV)是在大约70年前分离出来的，但在2016年之前几乎没有发表过实验研究。最近寨卡病毒在西半球国家的传播与小头畸形、先天性畸形和格林-巴利综合征的报告有关。这导致ZIKV被宣布为公共卫生紧急状态，并大大加快了ZIKV研究和发现的步伐。在很短的时间内，已经建立了有用的小鼠和非人类灵长类疾病模型，并开始了治疗和疫苗的临床前评估。出乎意料的是，ZIKV在身体组织和体液中表现出广泛的趋向性和持久性，这导致了在当前疫情中观察到的临床表现和流行病学。在这篇综述中，我们重点介绍了我们对ZIKV致病机制、组织嗜性和由此导致的病理的了解的最新进展，并讨论了未来研究的领域。
Although Zika virus (ZIKV) was isolated approximately 70 years ago, few experimental studies had been published prior to 2016. The recent spread of ZIKV to countries in the Western Hemisphere is associated with reports of microcephaly, congenital malformations and Guillain-Barré syndrome. This has resulted in ZIKV being declared a public health emergency and has greatly accelerated the pace of ZIKV research and discovery. Within a short time period, useful mouse and non-human primate disease models have been established, and pre-clinical evaluation of therapeutics and vaccines has begun. Unexpectedly, ZIKV exhibits a broad tropism and persistence in body tissues and fluids, which contributes to the clinical manifestations and epidemiology that have been observed during the current epidemic. In this review, we highlight recent advances in our understanding of ZIKV pathogenesis, tissue tropism and the resulting pathology, and discuss areas for future investigation.