Sickle hemoglobin aggregation: a new class of inhibitors.
Sickle hemoglobin aggregation: a new class of inhibitors.
复制标题
镰状血红蛋白聚集：一类新的抑制剂。
作者：
J. Votano;M. Gorecki;A. Rich
许多三肽和四肽已被发现可抑制脱氧镰状细胞血红蛋白的聚集和凝胶化。这些抑制剂一端具有疏水性的苯丙氨酸残基，另一端具有能形成氢键的赖氨酸或精氨酸侧链。主链不是非常特异。这些抑制剂不会改变血红蛋白的携氧特性。当将抑制剂和镰状血红蛋白置于重组细胞内时，红细胞在脱氧时不会变成镰状。这类化合物可能会发展成为治疗镰状细胞贫血的有用药物。
A number of tri- and tetrapeptides have been found to inhibit aggregation and gelation of deoxygenated sickle cell hemoglobin. These inhibitors have hydrophobic phenylalanine residues at one end and hydrogen bonding lysine or arginine side chains at the other end. The backbone is not very specific. The inhibitors do not modify the oxygen carrying properties of hemoglobin. When the inhibitor and sickle hemoglobin are put inside reconstituted cells, the erythrocytes do not sickle upon deoxygenation. Compounds of this type may develop useful agents in the therapy of sickle cell anemia.