2-Pyridone Formation: An Efficient Method for the Solid-Phase Synthesis of Homodimers.
2-Pyridone Formation: An Efficient Method for the Solid-Phase Synthesis of Homodimers.
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2-吡啶酮形成：同二聚体固相合成的有效方法。
DOI：
10.1002/chem.202302937
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Kodadek,Thomas
中科院分区：
文献类型：
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作者：
Abboud,SkanderA;Kodadek,Thomas
本研究提出了一种通过3，3-二甲氧基丙酸修饰的分子自缩合产生2-吡啶酮的树脂上二聚体的有效方法。该方法通过产生肽、类肽和非肽配体的同源二聚体证明了显著的通用性。其易于应用，广泛的实用性和温和的反应条件不仅对肽和类肽研究具有重要意义，而且还为广泛的二价配体的树脂开发提供了潜力。
This study presents an efficient method for on‐resin dimer generation through self‐condensation of 3,3‐dimethoxypropionic acid‐modified molecules, resulting in 2‐pyridones. The approach demonstrated remarkable versatility by producing homodimers of peptides, peptoids, and non‐peptidic ligands. Its ease of application, broad utility, and mild reaction conditions not only hold significance for peptide and peptoid research but also offer potential for the on‐resin development of a wide range of bivalent ligands.