Intravenous iron for the treatment of fatigue in nonanemic, premenopausal women with low serum ferritin concentration
Intravenous iron for the treatment of fatigue in nonanemic, premenopausal women with low serum ferritin concentration
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DOI：
10.1182/blood-2011-04-346304
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发表时间：
2011-09-22
期刊：
影响因子：
20.3
通讯作者：
Schulthess, Georg
中科院分区：
文献类型：
--
作者：
Krayenbuehl, Pierre-Alexandre;Battegay, Edouard;Schulthess, Georg
这是首次研究静脉注射铁治疗血清铁蛋白浓度低的非贫血患者疲劳的疗效。在一项随机、双盲、安慰剂对照研究中，90名血清铁蛋白= 120 g/L的绝经前妇女被随机分为两组，一组接受800 mg氢氧化铁蔗糖静脉注射，另一组接受安慰剂静脉注射。在基线、6周和12周后评估疲劳和血清铁水平。基线疲劳中位数为4.5（0-10分）。在最初的6周内，铁组的疲劳度下降了1.1，而安慰剂组为0.7 （P = .07）。铁的疗效与铁储备的耗尽有关：在基线血清铁蛋白的患者中
This is the first study to investigate the efficacy of intravenous iron in treating fatigue in nonanemic patients with low serum ferritin concentration. In a randomized, double-blinded, placebo-controlled study, 90 premenopausal women presenting with fatigue, serum ferritin = 120 g/L were randomized to receive either 800 mg of intravenous iron (III)-hydroxide sucrose or intravenous placebo. Fatigue and serum iron status were assessed at baseline and after 6 and 12 weeks. Median fatigue at baseline was 4.5 (on a 0-10 scale). Fatigue decreased during the initial 6 weeks by 1.1 in the iron group compared with 0.7 in the placebo group (P = .07). Efficacy of iron was bound to depleted iron stores: In patients with baseline serum ferritin