Pemoline produces ipsilateral turning behavior in unilateral 6-OHDA-lesioned rats.
Pemoline produces ipsilateral turning behavior in unilateral 6-OHDA-lesioned rats.
复制标题
Pemoline 在单侧 6-OHDA 损伤的大鼠中产生同侧转向行为。
DOI：
10.1016/0278-5846(96)00013-9
复制
发表时间：
1996
影响因子：
5.6
通讯作者：
King,BH
中科院分区：
文献类型：
--
作者：
Cromwell,HC;Witte,EA;Crawford,CA;Ly,HT;Maidment,NT;King,BH
1.1. Male Sprague-Dawley rats received either a unilateral injection of 6-hydroxy-dopamine or vehicle injection into the medial forebrain bundle.2.2. Two weeks post surgery, all rats received a pemoline challenge (250 mg/kg s.c.) and rotational and stereotyped behaviors were videotaped and analyzed.3.3. All rats regardless of injection expressed stereotyped behaviors and hyper-locomotion after pemoline challenge.4.4. High performance liquid chromatography (HPLC) with electrochemical detection was used to evaluate changes in the levels of dopamine, serotonin and their metabolites in neostriata.5.5. Rats with dopamine depleting lesions exhibited ipsilateral rotational behavior, indicating that pemoline, a central stimulant, is an indirect dopamine agonist in the rat.6.6. The extent of dopamine depletion and serotonin elevation in the neostriatum in lesioned animals was related to the expression and degree of rotational behavior.
