Human leucocyte antigen risk alleles for psoriatic arthritis among patients with psoriasis
Human leucocyte antigen risk alleles for psoriatic arthritis among patients with psoriasis
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DOI：
10.1136/ard.2011.155044
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发表时间：
2012-01-01
影响因子：
27.4
通讯作者：
Gladman, Dafna D.
中科院分区：
文献类型：
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作者：
Eder, Lihi;Chandran, Vinod;Gladman, Dafna D.
目的研究银屑病关节炎（PsA）与皮肤型银屑病（PsC）的差异基因，为银屑病患者PsA的发生发展提供分子标记。方法对712例PsA、335例PsC和713例健康对照者进行HLA-A、HLA-B、HLA-C、HLA-DR和HLA-DQ等位基因分型。使用似然比检验比较每个HLA基因座的等位基因分布差异。多个位点的Logistic回归分析进行解释连锁不平衡。结果在多因素回归分析中发现，与PsC患者相比，下列HLA等位基因与PsA患者显著相关：B * 08（OR 1.61，p = 0.009），B * 27（OR 5.17，p <0.01），B * 27（OR 1.61，p <0.01），B * 27（OR 5.17，p <0.01），B * 08（OR 1.61，p <0.01），B * 08（OR 1.61，p <0.01），B * 08（OR 5.17，p <0.01），B * 08（OR 1.61，p <0.01），B * 08（OR 5.17，p <0.01），B * 08（OR 1.61，p <0.01），B * 08（OR 1.61，p <0.01），B * 08（OR 1.61，p
Aim Genes that differentiate patients with psoriatic arthritis (PsA) from those with cutaneous psoriasis (PsC) may serve as markers for the development of PsA in patients with psoriasis. The authors aimed to identify human leucocyte antigen (HLA) alleles that are associated with the development of PsA in patients with psoriasis.Methods 712 adult patients with PsA, 335 adult patients with PsC and 713 healthy controls were genotyped for HLA-A, HLA-B, HLA-C, HLA-DR and HLA-DQ alleles. Differences in allelic distributions for each of the HLA loci were compared using a likelihood ratio test. Logistic regression analysis of multiple loci was performed to account for linkage disequilibrium. Haplotype information was inferred using the expectation-maximisation algorithm (given HLA-C and HLA-B genotypes) and analysed similarly.Results The following HLA alleles were found to be significantly associated with patients with PsA compared to patients with PsC in multivariate regression analysis: B*08 (OR 1.61, p=0.009), B*27 (OR 5.17, p