A simple electrical-mechanical model of the heart applied to the study of electrical-mechanical alternans.
A simple electrical-mechanical model of the heart applied to the study of electrical-mechanical alternans.
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一个简单的心脏机电模型，应用于机电交替的研究。
DOI：
10.1109/10.81580
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Cohen,RJ
中科院分区：
文献类型：
--
作者：
Clancy,EA;Smith,JM;Cohen,RJ
最近的证据表明，在表面心电图（电交替）的微妙交替可能与心室颤动的易感性。在目前的工作中，作者提出的证据表明，在心跳机械交替（机械交替）通常伴随着电交替。一个简单的有限元计算机模型，它模拟的电和机械活动的心脏。还报告了一项试点动物研究。计算机模型和动物研究都发现：（1）在从正常节律向节律性节律转变的过程中，存在一种电-机械交替的组合状态，（2）检测到的交替程度与节律的相对不稳定性相关，以及（3）电气和机械交替可能是由于局部电气特性的分散导致的空间-电传导过程中的时间交替。<>
Recent evidence has shown that a subtle alternation in the surface ECG (electrical alternans) may be correlated with the susceptibility to ventricular fibrillation. In the present work, the author presents evidence that a mechanical alternation in the heartbeat (mechanical alternans) generally accompanies electrical alternans. A simple finite-element computer model which emulates both the electrical and the mechanical activity of the heart is presented. A pilot animal study is also reported. The computer model and the animal study both found that (1) there exists a regime of combined electrical-mechanical alternans during the transition from a normal rhythm towards a fibrillatory rhythm, (2) the detected degree of alternation is correlated with the relative instability of the rhythm, and (3) the electrical and mechanical alternans may result from a dispersion in local electrical properties leading to a spatial-temporal alternation in the electrical conduction process.<>