Flexible Neural Electrode Array Based-on Porous Graphene for Cortical Microstimulation and Sensing.
Flexible Neural Electrode Array Based-on Porous Graphene for Cortical Microstimulation and Sensing.
复制标题
DOI：
10.1038/srep33526
复制
发表时间：
2016-09-19
影响因子：
4.6
通讯作者：
Kuzum D
中科院分区：
文献类型：
--
作者：
Lu Y;Lyu H;Richardson AG;Lucas TH;Kuzum D
几十年来，神经感觉和刺激一直是神经科学研究、脑机接口和临床神经调节疗法的支柱。到目前为止，大多数神经刺激系统都依赖于电化学性能较差的尖端金属微电极，这会对组织造成广泛的损伤，并显著降低植入性系统的长期稳定性。在这里，我们展示了一种基于多孔石墨烯的灵活的皮质微电极阵列，它能够从大脑表面进行有效的电生理传感和刺激，而不会渗透到组织中。多孔石墨烯电极表现出优异的阻抗和电荷注入特性，使其成为高效皮质传感和刺激的理想选择。即使在100万次双相刺激循环后，它们也没有表现出物理分层或降解，从而证实了高耐久性。在啮齿动物的活体实验中，同一阵列被用来以高时空分辨率感知大脑活动模式，并通过从皮质表面进行高精度电刺激来控制腿部肌肉。柔性多孔石墨烯阵列提供了一种微创但高效的神经调节方案，在皮质标测、脑机接口、神经疾病的治疗方面具有潜在的应用前景，其中高分辨率和同时记录和刺激神经活动至关重要。
Neural sensing and stimulation have been the backbone of neuroscience research, brain-machine interfaces and clinical neuromodulation therapies for decades. To-date, most of the neural stimulation systems have relied on sharp metal microelectrodes with poor electrochemical properties that induce extensive damage to the tissue and significantly degrade the long-term stability of implantable systems. Here, we demonstrate a flexible cortical microelectrode array based on porous graphene, which is capable of efficient electrophysiological sensing and stimulation from the brain surface, without penetrating into the tissue. Porous graphene electrodes show superior impedance and charge injection characteristics making them ideal for high efficiency cortical sensing and stimulation. They exhibit no physical delamination or degradation even after 1 million biphasic stimulation cycles, confirming high endurance. In in vivo experiments with rodents, same array is used to sense brain activity patterns with high spatio-temporal resolution and to control leg muscles with high-precision electrical stimulation from the cortical surface. Flexible porous graphene array offers a minimally invasive but high efficiency neuromodulation scheme with potential applications in cortical mapping, brain-computer interfaces, treatment of neurological disorders, where high resolution and simultaneous recording and stimulation of neural activity are crucial.
登录
查看更多内容
DOI：
10.1109/tnsre.2014.2342880
发表时间：
2015-05-01
影响因子：
4.9
作者：
Castagnola, Elisa;Maiolo, Luca;Ricci, Davide
通讯作者：
Ricci, Davide
影响因子：
29.4
作者：
Khodagholy, Dion;Doublet, Thomas;Malliaras, George G.
通讯作者：
Malliaras, George G.
影响因子：
29.4
作者：
Li, Lei;Zhang, Jibo;Tour, James M.
通讯作者：
Tour, James M.
影响因子：
158.5
作者：
Obeso, JA;Guridi, J;Wilkinson, S
通讯作者：
Wilkinson, S
影响因子：
10.8
作者：
Balandin, Alexander A.;Ghosh, Suchismita;Lau, Chun Ning
通讯作者：
Lau, Chun Ning