Cortex glia clear dead young neurons via Drpr/dCed-6/Shark and Crk/Mbc/dCed-12 signaling pathways in the developing Drosophila optic lobe.
Cortex glia clear dead young neurons via Drpr/dCed-6/Shark and Crk/Mbc/dCed-12 signaling pathways in the developing Drosophila optic lobe.
复制标题
皮层胶质细胞通过发育中的果蝇视叶中的 Drpr/dCed-6/Shark 和 Crk/Mbc/dCed-12 信号通路清除死亡的年轻神经元。
DOI：
10.1016/j.ydbio.2019.05.003
复制
发表时间：
2019
影响因子：
2.7
通讯作者：
and Tsujimura H.
中科院分区：
文献类型：
--
作者：
Nakano;R.;Iwamura;M.;Obikawa;A.;Togane;Y.;Hara;Y.;Fukuhara;T.;Tomaru;M.;Takano;T.;and Tsujimura H.
本文探讨了果蝇视叶发育过程中死亡神经元清除的分子和细胞机制。在视叶的发育过程中，许多神经细胞通过凋亡而死亡，并且尸体在蛹的早期阶段被立即移除。在视叶中死亡的大多数细胞是没有延伸神经突的年轻神经元。在这项研究中，我们发现，清除是由皮层胶质细胞通过一个吞噬受体，德雷珀（Drpr）。drpr在皮层胶质细胞从二龄幼虫到早期蛹阶段的清除是必需的，并足以。在其他胶质细胞亚型中表达的Drpr不介导清除。Shark和Ced-6介导Drpr的清除。Crk/Mbc/dCed-12通路部分参与清除，但作用较小。抑制Pretaporter，CaBP 1和磷脂酰丝氨酸延迟清除的功能，这表明这些分子在发育中的视叶中作为Drpr配体发挥作用的可能性。
The molecular and cellular mechanism for clearance of dead neurons was explored in the developingDrosophilaoptic lobe. During development of the optic lobe, many neural cells die through apoptosis, and corpses are immediately removed in the early pupal stage. Most of the cells that die in the optic lobe are young neurons that have not extended neurites. In this study, we showed that clearance was carried out by cortex glia via a phagocytosis receptor, Draper (Drpr).drprexpression in cortex glia from the second instar larval to early pupal stages was required and sufficient for clearance. Drpr that was expressed in other subtypes of glia did not mediate clearance. Shark and Ced-6 mediated clearance of Drpr. The Crk/Mbc/dCed-12 pathway was partially involved in clearance, but the role was minor. Suppression of the function of Pretaporter, CaBP1 and phosphatidylserine delayed clearance, suggesting a possibility for these molecules to function as Drpr ligands in the developing optic lobe.