Dietary supplementation with fish oil rich in ω-3 polyunsaturated fatty acids in children with bronchial asthma
Dietary supplementation with fish oil rich in ω-3 polyunsaturated fatty acids in children with bronchial asthma
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DOI：
10.1183/09031936.00.16586100
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发表时间：
2000-11-01
影响因子：
24.3
通讯作者：
Hata, K
中科院分区：
文献类型：
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作者：
Nagakura, T;Matsuda, S;Hata, K
欧米伽-3多不饱和脂肪酸在体外具有抗炎作用，高饮食水平与较低的炎症性疾病发生率相关。然而，仅在哮喘中证实了有限的效果。以随机对照的方式研究了 29 名支气管哮喘儿童膳食补充鱼油 10 个月的效果。为了尽量减少环境吸入过敏原和饮食的影响，本研究在一家长期治疗医院进行。受试者接受含有 84 毫克二十碳五烯酸 (EPA) 和 36 毫克二十二碳六烯酸 (DHA) 的鱼胶囊或含有 300 毫克橄榄油的对照胶囊。 EPA和DHA的每日剂量分别为17.0-26.8和7.3-11.5 mg.kg体重(-1)。鱼油组哮喘症状评分下降，对乙酰胆碱的反应性下降，但对照组没有这种情况。此外，血浆 EPA 水平仅在鱼油组中显着增加（p
omega -3 Polyunsaturated fatty acids have anti-inflammatory effects in vitro, and high dietary levels are associated with a lower incidence of inflammatory diseases. However, only limited effects have been demonstrated in asthma. The effects of dietary supplementation with fish oil for 10 months in 29 children with bronchial asthma was investigated in a randomized controlled fashion.In order to minimize the effects of environmental inhaled allergens and diet, this study was performed in a long-term treatment hospital. Subjects received fish oh capsules containing 84 mg eicosapentaenoic acid (EPA) and 36 mg docosahexaenoic acid (DHA) or control capsules containing 300 mg olive oil. The daily dosages of EPA and DHA were 17.0-26.8 and 7.3-11.5 mg.kg body weight(-1), respectively.Asthma symptom scores decreased and responsiveness to acetylcholine decreased in the fish oil group but not in the control group. In addition, plasma EPA levels increased significantly only in the fish oil group (p