Alcohol, physical activity and other risk factors for colorectal cancer: a prospective study.
Alcohol, physical activity and other risk factors for colorectal cancer: a prospective study.
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DOI：
10.1038/bjc.1987.140
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发表时间：
1987-06
影响因子：
8.8
通讯作者：
Henderson BE
中科院分区：
文献类型：
--
作者：
Wu AH;Paganini-Hill A;Ross RK;Henderson BE
在一个退休社区的11，888名居民中研究了结直肠癌的病因。经过四年半的随访，确定了58名男性和68名女性发生结肠直肠癌。每日饮酒者的风险增加了近两倍（双侧P = 0.002）。结直肠癌与克托莱指数呈正相关，与日常体力活动呈负相关。两种性别的结果一致，但仅男性具有统计学显著性。除了膳食维生素C外，研究中的营养素（即，维生素A和E、膳食纤维、钙和β-胡萝卜素）与结肠直肠癌有显著的相关性。在女性中观察到结直肠癌和膳食维生素C之间的负相关关系，但与补充剂中的维生素C或维生素C总摄入量无关。有3个或3个以上子女的男性和女性结直肠癌的风险显著降低（RR = 0.45，95%CI = 0.2，0.9），但没有子女的人没有显示出最高的风险。
The aetiology of colorectal cancer was studied in a cohort of 11,888 residents of a retirement community. After four and one-half years of follow-up, 58 male and 68 female incident colorectal cancers were identified. Daily alcohol drinkers experienced nearly a two-fold increase in risk (2 sided P = 0.002). Colorectal cancer was also positively associated with Quetelet's index and inversely associated with avocational physical activity. The results were consistent for both sexes but were statistically significant only for males. With the exception of dietary vitamin C, none of the nutrients under study (i.e., vitamins A and E, dietary fibre, calcium, and beta carotene) showed a significant association with colorectal cancer. An inverse relationship between colorectal cancer and dietary vitamin C was observed in females, but there was no association with either vitamin C from supplements or with total vitamin C intake. Males and females who had 3 or more children showed a significantly reduced risk of colorectal cancer (RR = 0.45, 95% CI = 0.2, 0.9), but those with no children did not show the highest risk.