The looped heart does not save energy by maintaining the momentum of blood flowing in the ventricle
The looped heart does not save energy by maintaining the momentum of blood flowing in the ventricle
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DOI：
10.1152/ajpheart.00041.2008
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发表时间：
2008-05-01
影响因子：
4.8
通讯作者：
Hisada, Toshiaki
中科院分区：
文献类型：
--
作者：
Watanabe, Hiroshi;Sugiura, Seiryo;Hisada, Toshiaki
以往的研究表明，重建或维持心脏中的生理血流通道对于心脏手术后获得良好的结果很重要，但这一概念没有建立的理论基础。我们开发了一个多尺度，多物理场心脏模拟器，基于有限元方法，并比较了心室的血流动力学与生理和非生理流路。我们发现，生理流动路径没有节能效果，但有助于流出和流入路径的分离，从而避免血液的任何混合。心室壁所做的功在较慢和较快的心率下相当（生理与非生理，0.864与0.874 J，心率= 60次/min;以及0.599与0.590 J，心率= 100次/min），表明哺乳动物心脏中流动路径的手性不对称性具有最小的功能优点。在较低的心率下，在两种模型中，第一次心跳中的血液几乎完全被第九次心跳清除。然而，在高心率下，仅在生理模型中观察到这种完全清除，而在非生理模型中仍有27.0%的血液。这种多尺度心脏模拟器提供了心脏力学和血流动力学的详细信息，可以成为心脏生理学的有用工具。
Previous studies suggested that the reconstruction or maintenance of physiological blood flow paths in the heart is important to obtain a good outcome following cardiac surgery, but this concept has no established theoretical foundation. We developed a multiscale, multiphysics heart simulator, based on the finite element method, and compared the hemodynamics of ventricles with physiological and nonphysiological flow paths. We found that the physiological flow path did not have an energy-saving effect but facilitated the separation of the outflow and inflow paths, so avoiding any mixing of the blood. The work performed by the ventricular wall was comparable at slower and faster heart rates (physiological vs. nonphysiological, 0.864 vs. 0.874 J, heart rate = 60 beats/min; and 0.599 vs. 0.590 J, heart rate = 100 beats/min), indicating that chiral asymmetry of the flow paths in the mammalian heart has minimal functional merit. At lower heart rates, the blood coming in the first beat was cleared almost completely by the ninth beat in both models. However, at high heart rates, such complete clearance was observed only in the physiological model, whereas 27.0% of blood remained in the nonphysiological model. This multiscale heart simulator provided detailed information on the cardiac mechanics and flow dynamics and could be a useful tool in cardiac physiology.