The Central Nervous System as a Sanctuary Site in ALK-Positive Non-Small-Cell Lung Cancer
The Central Nervous System as a Sanctuary Site in ALK-Positive Non-Small-Cell Lung Cancer
复制标题
DOI：
10.1097/jto.0000000000000029
复制
发表时间：
2013-12-01
影响因子：
20.4
通讯作者：
Shaw, Alice T.
中科院分区：
文献类型：
--
作者：
Gainor, Justin F.;Ou, Sai-Hong Ignatius;Shaw, Alice T.
间变性淋巴瘤激酶（ALK）基因重排定义了对ALK抑制剂克唑替尼治疗高度敏感的非小细胞肺癌的一个独特分子亚群。最近，人们认识到大脑是接受克唑替尼治疗的ALK阳性患者的常见复发部位。在这份报告中，我们扩展了这些观察结果，并提出了一系列ALK阳性患者的两种不同形式的转移，中枢神经系统的参与：髓内脊髓转移和软脑膜癌病。
Anaplastic lymphoma kinase (ALK) gene rearrangements define a distinct molecular subset of non-small-cell lung cancer that is highly responsive to treatment with the ALK inhibitor crizotinib. Recently, it has been recognized that the brain is a frequent site of relapse among ALK-positive patients treated with crizotinib. In this report, we expand on these observations and present a series of ALK-positive patients with two distinct forms of metastatic, central nervous system involvement: intramedullary spinal cord metastasis and leptomeningeal carcinomatosis.