Labyrinthectomy decreases bone mineral density in the femoral metaphysis in rats.
Labyrinthectomy decreases bone mineral density in the femoral metaphysis in rats.
复制标题
迷路切除术降低了大鼠股骨干骺端的骨矿物质密度。
DOI：
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发表时间：
2004
影响因子：
2.3
通讯作者：
A. Reber
中科院分区：
文献类型：
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作者：
R. Levasseur;J. Sabatier;O. Etard;P. Denise;A. Reber
为了确定前庭系统是否影响大鼠的骨重建，我们在双侧迷路切除前和术后30天用双能X射线骨密度仪测量了骨密度。与正常对照组相比，迷路切除组大鼠股骨远端干骺端骨密度降低(p=0.007)：对照组D0~D30的变化为+3.0%，去迷路大鼠为-13.9%。全身骨密度两组间差异无统计学意义。这些结果表明，外周前庭装置是骨量的调节器，更具体地说，是承重骨的调节器。我们讨论了这种前庭影响的可能机制，可能是由交感神经系统介导的。
To determine whether the vestibular system could influence bone remodeling in rats, we measured bone mineral density with dual energy X-rays absorptiometry before and 30 days after bilateral labyrinthectomy. Comparatively to intact control rats, labyrinthectomized animals showed a reduced bone mineral density in distal femoral metaphysis (p = 0.007): the variations between D0 and D30 were +3.0% for controls and -13.9% for labyrinthectomized rats. No significant difference between the 2 groups was observed in the whole body mineral density. These results suggest that the peripheral vestibular apparatus is a modulator of bone mass and more specifically in weight bearing bone. We discuss possible mechanisms of this vestibular influence probably mediated by the sympathetic nervous system.
DOI：
10.3233/ves-1998-8103
发表时间：
1998
期刊：
Journal of vestibular research : equilibrium & orientation
影响因子：
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作者：
B. Yates;Alan D. Miller
通讯作者：
B. Yates;Alan D. Miller