A MECHANISM FOR MEMORY STORAGE INSENSITIVE TO MOLECULAR TURNOVER - A BISTABLE AUTOPHOSPHORYLATING KINASE
A MECHANISM FOR MEMORY STORAGE INSENSITIVE TO MOLECULAR TURNOVER - A BISTABLE AUTOPHOSPHORYLATING KINASE
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DOI：
10.1073/pnas.82.9.3055
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发表时间：
1985-01-01
影响因子：
11.1
通讯作者：
LISMAN, JE
中科院分区：
文献类型：
--
作者：
LISMAN, JE
有人提出了一种分子开关的机制，它可以无限期地存储信息，尽管组成开关的分子完全周转。这种开关的设计是基于已知类型的生化反应。该机制的核心是一种被磷酸化激活并能够在分子间自动磷酸化的激酶。这种激酶和相关的磷酸酶形成了一个双稳态的化学开关，可以通过外部刺激来启动，而不是通过蛋白质周转来重置。
A mechanism is proposed for a molecular switch that can store information indefinitely, despite the complete turnover of the molecules that make up the switch. The design of the switch is based on known types of biochemical reactions. Central to the mechanism is a kinase that is activated by phosphorylation and is capable of intermolecular autophosphorylation. Such a kinase and an associated phosphatase form a bistable chemical switch that can be turned on by an external stimulus and that is not reset by protein turnover.