VERDICT-MRI Analysis of False Positives in Prostate Mp-MRI
VERDICT-MRI Analysis of False Positives in Prostate Mp-MRI
复制标题
前列腺 Mp-MRI 假阳性的 VERDICT-MRI 分析
DOI：
10.58530/2022/0926
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Eleftheria Panagiotaki
中科院分区：
文献类型：
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作者：
Snigdha Sen;V. Valindria;H. Pye;A. Grey;A. Haider;A. Freeman;C. Moore;H. Whitaker;S. Punwani;Saurabh Singh;Eleftheria Panagiotaki
Mp-MRI对前列腺癌的诊断具有中等的特异性，导致许多假阳性结果和其他前列腺疾病患者不必要的活检。这项工作提出了一种方法，使用VERDICT-MRI研究正常前列腺组织，假阳性病变和临床显著的癌症之间的微结构参数估计的差异。VERDICT细胞内体积分数和细胞外-血管外间隙的固有扩散率可以比mp-MRI的临床ADC更准确地区分假阳性病变。这些结果表明，VERDICT有可能识别假阳性，减少前列腺患者不必要的活检。
Mp-MRI has moderate specificity for the diagnosis of prostate cancer, resulting in many false positive results and unnecessary biopsies for patients with other prostatic diseases. This work presents an approach using VERDICT-MRI to investigate differences in microstructural parameter estimates between normal prostate tissue, false positive lesions and clinically-significant cancer. The VERDICT intracellular volume fraction and intrinsic diffusivity in the extracellular-extravascular space can discriminate false positive lesions with greater accuracy than the clinical ADC from mp-MRI. These results show VERDICT has the potential to identify false positives and reduce unnecessary biopsies in prostate patients.