Changes in motor cortical excitability induced by high-frequency repetitive transcranial magnetic stimulation of different stimulation durations
Changes in motor cortical excitability induced by high-frequency repetitive transcranial magnetic stimulation of different stimulation durations
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DOI：
10.1016/j.clinph.2007.09.124
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发表时间：
2008-01-01
影响因子：
4.7
通讯作者：
Shin, Hyung-Ik
中科院分区：
文献类型：
--
作者：
Jung, Se Hee;Shin, Jae Eun;Shin, Hyung-Ik
目的：目的：研究不同刺激时间的高频重复经颅磁刺激（rTMS）对运动皮层兴奋性的影响。受试者在左侧第一背侧骨间肌（17131）的运动热点上接受20列10 Hz rTMS，强度为静息运动阈值（RMT）的80%，刺激持续时间为5和1.5 s。肌电反应在放松的FDI肌肉中，在rTMS之前、之后立即和之后30、60、90和120 min，测量了双侧对单脉冲刺激的运动诱发电位（motor-evoked potentials，MEP），以及对脉冲刺激的皮质内抑制（ICI）和皮质内易化（ICF）。10 Hz rTMS 5 s后，刺激M1皮层MEP平均振幅下降达90 min（P = 0.002），未刺激M1皮层MEP平均振幅下降达60 min（P = 0.008）。10 Hz rTMS 5 s后，刺激（P = 0.0 0 1）和未刺激（P = 0.0 0 3）的MI皮质均观察到ICI增强和ICF抑制，并持续90 min以上。10 Hz rTMS 1.5 s后，刺激皮层MEP的平均振幅增加，持续120 min结论：高频阈下rTMS在不同刺激时间下，可引起健康受试者运动皮层皮质脊髓和皮质内兴奋性的不同变化。这些结果对rTMS频率以外的刺激参数的选择具有重要意义。rTMS用于运动增强的临床应用应与不同刺激参数的机制一起考虑沿着。(c)2007年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: To investigate the changes in cortical excitability of the human motor cortex induced by high-frequency repetitive transcranial magnetic stimulation (rTMS) of different stimulation durations.Methods: Twenty healthy subjects participated in the study. Subjects received 20 trains of 10-Hz rTMS at 80% of the resting motor threshold (RMT) intensity with two different stimulation durations (5 and 1.5 s) over the motor hot spot for left first dorsal interosseous (17131) muscle. Electromyographic responses (motor-evoked potentials, MEPs) to single-pulse stimulation, and intracortical inhibition (ICI) and intracortical facilitation (ICF) by paired-pulse stimulation were measured bilaterally in the relaxed FDI muscles before, immediately after, and 30, 60, 90 and 120 min after rTMS.Results: After 5 s of 10-Hz rTMS, the mean amplitude of MEP for the stimulated M I cortex decreased for up to 90 min (P = 0.002) and that of the unstimulated M1 cortex decreased for up to 60 min (P = 0.008). Enhancement of ICI and suppression of ICF were observed and sustained for more than 90 min in both stimulated (P = 0.001) and unstimulated (P = 0.003) M I cortex after 5 s of 10-Hz rTMS. After 1.5 s of 10-Hz rTMS, the mean amplitude of MEP increased in stimulated cortex for up to 120 min (P = 0.005).Conclusions: With different stimulation durations, high-frequency subthreshold rTMS can produce different patterns of long-lasting changes in corticospinal and intracortical excitability in stimulated and unstimulated motor cortex in healthy subjects.Significance: The results have important implications for the selection of stimulation parameters other than the frequency of rTMS. The clinical application of rTMS for the purpose of motor enhancement should be considered along with the mechanism of different stimulation parameters. (c) 2007 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.