Loss of ARID1A expression predicts poor survival prognosis in gastric cancer: a systematic meta-analysis from 14 studies.
Loss of ARID1A expression predicts poor survival prognosis in gastric cancer: a systematic meta-analysis from 14 studies.
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ARID1A 表达缺失预示胃癌生存预后不佳：14 项研究的系统荟萃分析
DOI：
10.1038/srep28919
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发表时间：
2016-06-29
影响因子：
4.6
通讯作者：
Xiong H
中科院分区：
文献类型：
--
作者：
Yang L;Wei S;Zhao R;Wu Y;Qiu H;Xiong H
染色质重塑基因，即富含at的相互作用结构域1A基因（ARID1A），在胃癌（GC）中经常发生无活性突变。然而，其预后价值仍有争议。为了解决这个问题，我们进行了全面的meta分析。系统检索了2016年3月之前发表的研究。本荟萃分析共纳入14篇文献的15个队列，涉及3183例患者。汇总数据显示，ARID1A表达缺失预测GC总生存期（OS）较差(风险比(HR) = 1.60；95%置信区间(CI) = 1.40-1.81；P< 0.001)，这些研究的异质性较低（I2= 21.5%；P= 0.214）。分层分析显示，亚洲人ARID1A表达缺失与不良OS相关（HR = 1.65, 95% CI = 1.44-1.89），近端疾病比例≤30%亚组（HR = 1.80, 95% CI = 1.36-2.38）和eb病毒（EBV）(+) > 5%亚组（HR = 1.59, 95% CI = 1.18-2.15）。敏感性分析表明结果可靠，未发现显著发表偏倚的证据。本研究证实了GC中ARID1A表达缺失与不良OS之间的显著关系。此外，种族、肿瘤位置和EBV感染状况可能是影响这种相关性的潜在关键因素。
The chromatin remodeling gene, AT-rich interactive domain 1A gene (ARID1A), frequently mutates inactively in gastric cancer (GC). However, its prognostic value remains controversial. To address this issue, a comprehensive meta-analysis was performed. Studies published until March 2016 were systematically searched. A total of 15 cohorts from 14 literatures involving 3183 patients were subjected to this meta-analysis. The pooled data showed that ARID1A expression loss predicted poor overall survival (OS) in GC (Hazard Ratio (HR) = 1.60; 95% Confidence Interval (CI) = 1.40–1.81;P< 0.001), with low heterogeneity among these studies (I2= 21.5%;P= 0.214). Stratification analyses revealed that ARID1A expression loss was associated with poor OS in Asians (HR = 1.65, 95% CI = 1.44–1.89), proportion of proximal disease ≤30% subgroup (HR = 1.80, 95% CI = 1.36–2.38) and Epstein-Barr virus (EBV) (+) > 5% subgroup (HR = 1.59, 95% CI = 1.18–2.15). The robust results were suggested by sensitivity analyses and no evidence of significant publication bias was detected. This study demonstrated a significant relationship between deletion of ARID1A expression and poor OS in GC. Moreover, ethnicity, tumor location and EBV infection status might be potential key factors influencing this correlation.