Radiation resistance of cancer stem cells: the 4 R's of radiobiology revisited.
Radiation resistance of cancer stem cells: the 4 R's of radiobiology revisited.
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DOI：
10.1002/stem.318
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发表时间：
2010-04
期刊：
影响因子：
5.2
通讯作者：
McBride, William H.
中科院分区：
文献类型：
--
作者：
Pajonk, Frank;Vlashi, Erina;McBride, William H.
There is compelling evidence that many solid cancers are organized hierarchically and contain a small population of cancer stem cells (CSCs). It seems reasonable to suggest that a cancer cure can be achieved only if this population is eliminated. Unfortunately, there is growing evidence that CSCs are inherently resistant to radiation, and perhaps other cancer therapies. In general, success or failure of standard clinical radiation treatment is determined by the 4 R’s of radiobiology: repair of DNA damage, redistribution of cells in the cell cycle, repopulation, and reoxygenation of hypoxic tumor areas. We relate recent findings on CSCs to these four phenomena and discuss possible consequences.
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影响因子：
11.2
作者：
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影响因子：
3.5
作者：
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Ober, A
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DOI：
10.1083/jcb.200806104
发表时间：
2008-10-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Campa VM;Gutiérrez-Lanza R;Cerignoli F;Díaz-Trelles R;Nelson B;Tsuji T;Barcova M;Jiang W;Mercola M
通讯作者：
Mercola M
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影响因子：
3.7
作者：
Chiou, Shih-Hwa;Kao, Chung-Lan;Chen, Yi-Wei;Chien, Chien-Shu;Hung, Shih-Chieh;Lo, Jeng-Fan;Chen, Yann-Jang;Ku, Hung-Hai;Hsu, Ming-Ta;Wong, Tai-Tong
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Wong, Tai-Tong
DOI：
10.1016/j.ijrobp.2009.07.001
发表时间：
2009-11-15
影响因子：
7
作者：
Al-Assar, Osama;Muschel, Ruth J.;Brunner, Thomas B.
通讯作者：
Brunner, Thomas B.