Magneto-nanosensor smartphone platform for the detection of HIV and leukocytosis at point-of-care
Magneto-nanosensor smartphone platform for the detection of HIV and leukocytosis at point-of-care
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DOI：
10.1016/j.nano.2018.11.007
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发表时间：
2019-02-01
影响因子：
5.4
通讯作者：
Wang, Shan X.
中科院分区：
文献类型：
--
作者：
Ng, Elaine;Yao, Chengyang;Wang, Shan X.
个体化医疗的出现使普通消费者对个人健康的兴趣增加。因此，非常需要以用户为中心的护理点（POC）健康设备。这些设备在发展中国家或资源有限的环境中同样适用于进行诊断测试。然而，目前用于人类免疫缺陷病毒（HIV）或白细胞增多症等疾病的POC检测不能提供足够的灵敏度水平或根本不存在。在这里，我们将我们的移动的磁纳米传感器平台扩展到即时艾滋病毒和白细胞增多检测。该平台可以被多路复用，并且该电路在POC设置中实现便携性和灵敏度。智能手机应用程序简化了操作，并提供指导，以促进自我测试。市售的POC检测试剂盒通常仅提供单一分析物的定性或半定量结果。磁纳米传感器平台可以为用户提供愉快的用户体验，同时展示了对常见疾病的稳健、灵敏和特异的多路复用量化和检测。爱思唯尔公司出版
The advent of personalized medicine has brought an increased interest in personal health among general consumers. As a result, there is a great need for user-centric point-of-care (POC) health devices. Such devices are equally pertinent in developing countries or resource-limited settings for performing diagnostic tests. However, current POC tests for diseases such as human immunodeficiency virus (HIV) or leukocytosis do not provide adequate levels of sensitivity or do not exist at all. Here, we extend our mobile magneto-nanosensor platform to point-of-care HIV and leukocytosis detection. The platform can he multiplexed, and the circuitry enables portability and sensitivity in the POC setting. A smartphone application simplifies operation and provides guidance to facilitate self-testing. Commercially available POC test kits typically provide only qualitative or semi-quantitative results of a single analyte. The magneto-nanosensor platform can provide users with pleasant user-experience while demonstrating robust sensitive and specific multiplexed quantification and detection of common diseases. Published by Elsevier Inc.