The Potential of Transcranial Alternating Current Stimulation to Alleviate Dual-Task Gait Costs in Older Adults: Insights from a Double-Blinded Pilot Study.
The Potential of Transcranial Alternating Current Stimulation to Alleviate Dual-Task Gait Costs in Older Adults: Insights from a Double-Blinded Pilot Study.
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经颅交流电刺激减轻老年人双重任务步态成本的潜力：双盲试点研究的见解。
DOI：
10.1159/000527171
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发表时间：
2023
期刊：
影响因子：
3.5
通讯作者：
Hausdorff,JeffreyM
中科院分区：
文献类型：
--
作者：
Sayig-Keren,RonyM;Dagan,Moria;CornejoThumm,Pablo;Brozgol,Marina;Gazit,Eran;Manor,Brad;Hausdorff,JeffreyM
在老年人中，行走时执行需要注意力的任务，即双重任务，会导致双重任务成本（例如，步态速度降低）。先前的研究表明，步态中的双重任务成本与未来的福尔斯和认知能力下降有关。根据相干性沟通假说，经颅交流电刺激（tACS）可能有助于缓解这一问题。本研究的目的是研究单次theta-tACS针对左额顶叶网络（L-FPN）对双任务行走和认知功能的影响，与假刺激和经颅直流电刺激（tDCS）针对左背外侧前额叶皮层相比，一个节点内的L-FPN。MethodsTwenty老年人完成了一个四次访问，双盲，受试者内，交叉研究中，通常步行，双任务步行，和认知功能进行评估之前和之后立即20分钟的tACS，tDCS，或假（顺序随机）刺激。双任务成本步态速度（主要结果）和其他measurements.ResultsThe双任务成本步态速度往往较低（即更好）后tACS（p= 0.067，科恩的标准差= 0.433小）; tDCS显着降低了这双任务成本（p= 0.012，科恩的标准差= 0.618中等），假刺激没有影响（p= 0.467）。tACS显著降低了步长的双任务成本（p= 0.037，Cohen'sd= 0.502 μ m中等）; tDCS后观察到一种趋势（p= 0.069，Cohen'sd= 0.443 μ m小）。步态或认知function.ConclusionsThe积极的影响tACS双任务步态速度和步长的其他措施没有发现统计学差异大致相似，看到与tDCS。这些结果表明，tACS影响额顶叶网络，类似于tDCS，tACS可以改善双任务。尽管如此，为了获得更大的益处并区分tACS和tDCS对老年人脑功能和双任务行走的影响，应测试其他刺激蒙太奇和方案。
BackgroundThe performance of an attention-demanding task while walking, ie, dual-tasking, leads to dual-task costs (eg, reduced gait speed) in older adults. Previous studies have shown that dual-task costs in gait are associated with future falls and cognitive decline. According to the communication through coherence hypothesis, transcranial alternating current stimulation (tACS) might help alleviate this problem.ObjectiveThe aim of this study was to examine the effects of a single session of theta-tACS targeting the left fronto-parietal network (L-FPN) on dual-task walking and cognitive function compared to sham stimulation and transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex, a node within the L-FPN.MethodsTwenty older adults completed a four-visit, double-blinded, within-subject, cross-over study in which usual-walking, dual-task walking, and cognitive function were evaluated before and immediately after 20 min of tACS, tDCS, or sham (order randomized) stimulation. Dual-task costs to gait speed (primary outcome) and other measures were analyzed.ResultsThe dual-task cost to gait speed tended to be lower (ie, better) after tACS (p= 0.067, Cohen’sd= 0.433∼ small); tDCS significantly reduced this dual-task cost (p= 0.012, Cohen’sd= 0.618∼ medium), and sham stimulation had no effect (p= 0.467). tACS significantly reduced the dual-task cost to step length (p= 0.037, Cohen’sd= 0.502∼ medium); a trend was seen after tDCS (p= 0.069, Cohen’sd= 0.443∼ small). No statistical differences were found for other measures of gait or cognitive function.ConclusionsThe positive effects of tACS on dual-task gait speed and step length were roughly similar to those seen with tDCS. These results suggest that tACS affects the fronto-parietal network and, similar to tDCS, tACS may improve dual-tasking. Nonetheless, to achieve larger benefits and differentiate the effects of tACS and tDCS on brain function and dual-task walking in older adults, other stimulation montages and protocols should be tested.