The relationship of urinary 3-phenoxybenzoic acid concentrations in utero and during childhood with adiposity in 4-year-old children
The relationship of urinary 3-phenoxybenzoic acid concentrations in utero and during childhood with adiposity in 4-year-old children
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DOI：
10.1016/j.envres.2019.02.037
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发表时间：
2019-05-01
影响因子：
8.3
通讯作者：
Hong, Yun-Chul
中科院分区：
文献类型：
--
作者：
Lee, Kyung-Shin;Lee, Young Ah;Hong, Yun-Chul
背景：据报道，拟除虫菊酯类杀虫剂是世界上最常用的住宅杀虫剂。我们的目的是研究产前和产后3-苯氧苯甲酸（3-PBA）浓度与4岁儿童生长和肥胖参数的关系。方法：我们从2008年8月至2011年7月期间参加儿童环境与发展（EDC）前瞻性研究的578名儿童中获得数据，这些儿童年龄在4岁左右（45-55个月）。在4岁时进行人体测量。分别在妊娠20周左右和4岁儿童的母体尿液样本中测量产前和产后尿液3-PBA浓度。结果产妇尿3-PBA（几何平均浓度）检出率为98 ~ 99% (0.98 μ g/g Cr)， 4岁儿童尿3-PBA检出率为99 ~ 100% （1.34 μ g/g Cr）。产前尿3- pba浓度与4岁时的身高、体重或身体质量指数（BMI） z分数无关，与性别无关。产后尿3- pba浓度与身高z-score无相关性，但与体重z-score呈正相关，且仅在女孩中有边际意义（p = 0.058）。按性别分析，校正协变量后，女孩产后尿3-PBA浓度与BMI z-score之间存在显著相关（p = 0.015）。结论：4岁儿童尿3-PBA浓度与4岁女孩BMI z-score呈正相关，而中期妊娠产前尿3-PBA浓度无相关性。
Background: Pyrethroid pesticides are reported to be the most commonly used residential insecticides worldwide. We aimed to investigate the relationship between prenatal and postnatal 3-phenoxybenzoic acid (3-PBA) concentrations, and growth and adiposity parameters in 4-year-old children.Method: We obtained data from 578 children who participated in the prospective Environment and Development of Children (EDC) study at around 4 years of age (45-55 months) between August 2008 and July 2011. Anthropometric measurements were obtained at age 4 years. Prenatal and postnatal urinary 3-PBA concentration was measured in maternal urine samples at around 20 weeks of gestation, and in the 4-year-old children, respectively.Result The detection frequency of urinary 3-PBA (geometric mean concentration) was 98-99% (0.98 mu g/g Cr) in maternal urine, and almost 99-100% (1.34 mu g/g Cr) in 4-year-old children. Prenatal urinary3-PBA concentration was not associated with height, weight, or body mass index (BMI) z-scores at 4 years of age, regardless of sex. Postnatal urinary3-PBA concentration was not related to height z-scores, but was positively associated with weight z-scores with marginal significance among only girls (p = 0.058). Analyzed by sex, there was a significant relationship between postnatal urinary 3-PBA concentration and BMI z-scores (p = 0.015) among girls, after adjusting for covariates.Conclusion: Childhood urinary 3-PBA concentration measured at 4 years of age was positively associated with BMI z-scores in 4-year-old girls, but prenatal urinary 3-PBA concentration at midterm pregnancy exhibited no association.