Asymmetric addition of dimethylzinc to N-tosylarylimines catalyzed by a rhodium-diene complex toward the synthesis of chiral 1-arylethylamines
Asymmetric addition of dimethylzinc to N-tosylarylimines catalyzed by a rhodium-diene complex toward the synthesis of chiral 1-arylethylamines
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DOI：
10.1021/ol060213e
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发表时间：
2006-03-02
期刊：
影响因子：
5.2
通讯作者：
Hayashi, T
中科院分区：
文献类型：
--
作者：
Nishimura, T;Yasuhara, Y;Hayashi, T
(RR)-2，5-二苯基双环[2.2.2]八-2，5-二烯(Ph-BOD*)配合物催化二甲基锌与N-对甲苯磺酰亚胺的不对称加成反应，得到高对映选择性(94-98%ee)的手性1-芳基-1-乙胺。
A rhodium complex coordinated with a chiral diene, (RR)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene (Ph-bod*), catalyzed the asymmetric addition of dimethylzinc to N-tosylarylimines to give high yields of chiral 1-aryl-1-ethylamines with high enantioselectivity (94-98% ee).