Exploiting the enantioselectivity of Baeyer-Villiger monooxygenases via boron oxidation
Exploiting the enantioselectivity of Baeyer-Villiger monooxygenases via boron oxidation
复制标题
DOI：
10.1016/j.tetasy.2012.05.004
复制
发表时间：
2012-05-15
影响因子：
--
通讯作者：
Andrade, Leandro H.
中科院分区：
文献类型：
--
作者：
Brondani, Patricia B.;Dudek, Hanna;Andrade, Leandro H.
研究了Baeyer-Villiger单加氧酶对几种手性含硼化合物的碳-硼键对映选择性氧化反应。PAMO和M446 G PAMO方便地将1-苯乙基硼酸酯氧化成相应的1-（苯基）乙醇（ee = 82-91%）。环丙基硼酸酯也被氧化，但没有对映选择性。β-硼基羧酸酯不被任何BVMO氧化。(C)2012爱思唯尔有限公司保留所有权利。
The enantioselective carbon-boron bond oxidation of several chiral boron-containing compounds by Baeyer-Villiger monooxygenases was evaluated. PAMO and M446G PAMO conveniently oxidized 1-phenylethyl boronate into the corresponding 1-(phenyl)ethanol (ee = 82-91%). Cyclopropyl boronic esters were also oxidized but with no enantioselectivity. beta-Boryl carboxylic esters were not oxidized by any BVMOs. (C) 2012 Elsevier Ltd. All rights reserved.