Assessment of rates of structural change in glaucoma using imaging technologies
Assessment of rates of structural change in glaucoma using imaging technologies
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DOI：
10.1038/eye.2010.202
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发表时间：
2011-03-01
期刊：
影响因子：
3.9
通讯作者：
Weinreb, R. N.
中科院分区：
文献类型：
--
作者：
Mansouri, K.;Leite, M. T.;Weinreb, R. N.
目的回顾现有影像学技术对青光眼患者结构变化率的评估能力。患者与方法文献回顾。结果共聚焦扫描激光检眼镜（CSLO）、扫描激光偏振仪（SLP）和光学相干断层扫描（OCT）等成像技术可对视盘和视网膜乳头旁神经纤维层（RNFL）进行可量化和可重复性的测量。通过边缘面积（RA）（用于CSLO）和RNFL厚度（用于SLP和OCT）量化的变化率与常规方法（例如，视野和视盘摄影）检测的青光眼进展有关。有证据表明，进展性青光眼患者的RNFL和RA丧失率明显快于非进展性青光眼患者。结论视盘变化率和RNFL变化率的测量越来越精确和个性化。目前可用的成像技术有能力检测和量化青光眼的进展，它们的测量可能是青光眼临床试验的合适终点。眼科学（2011）25,269-277；doi: 10.1038 / eye.2010.202;2011年1月7日在线发布
Purpose To review the ability of current imaging technologies to provide estimates of rates of structural change in glaucoma patients.Patients and methods Review of literature.Results Imaging technologies, such as confocal scanning laser ophthalmoscopy (CSLO), scanning laser polarimetry (SLP), and optical coherence tomography (OCT), provide quantifiable and reproducible measurements of the optic disc and parapapillary retinal nerve fibre layer (RNFL). Rates of change as quantified by the rim area (RA) (for CSLO) and RNFL thickness (for SLP and OCT) are related to glaucoma progression as detected by conventional methods (eg, visual fields and optic disc photography). Evidence shows that rates of RNFL and RA loss are significantly faster in progressing compared with non-progressing glaucoma patients.Conclusion Measurements of rates of optic disc and RNFL change are becoming increasingly precise and individualized. Currently available imaging technologies have the ability to detect and quantify progression in glaucoma, and their measurements may be suitable end points in glaucoma clinical trials. Eye (2011) 25, 269-277; doi:10.1038/eye.2010.202; published online 7 January 2011