Onset of maternal arterial blood flow and placental oxidative stress - A possible factor in human early pregnancy failure
Onset of maternal arterial blood flow and placental oxidative stress - A possible factor in human early pregnancy failure
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DOI：
10.1016/s0002-9440(10)64849-3
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发表时间：
2000-12-01
影响因子：
6
通讯作者：
Burton, GJ
中科院分区：
文献类型：
--
作者：
Jauniaux, E;Watson, AL;Burton, GJ
目的是测量与妊娠头三个月末母体动脉循环开始相关的人胎盘内氧张力的变化，以及对胎盘组织的影响。使用多参数探针，我们确定氧张力在第 12 周时从 50 mmHg 急剧上升，这种上升与允许母体血液自由流入胎盘的子宫动脉的形态变化一致，并且与胎盘组织内抗氧化酶过氧化氢酶、谷胱甘肽过氧化物酶、锰和铜/锌超氧化物歧化酶的 mRNA 浓度和活性的增加有关。 8至9周之间，热休克蛋白70的诱导型表达出现尖峰，硝基酪氨酸残基形成，合体滋养层内线粒体嵴紊乱。我们得出的结论是，当母体循环建立时，正常胎盘中会发生大量氧化应激。我们推测，这可能在刺激正常胎盘分化方面发挥生理作用，但如果抗氧化防御能力耗尽，也可能是先兆子痫和早期妊娠失败的发病机制的一个因素。
The aim was to measure changes in the oxygen tension within the human placenta associated with onset of the maternal arterial circulation at the end of the first trimester of pregnancy, and the impact on placental tissues. Using a multiparameter probe we established that the oxygen tension rises steeply from 50 mmHg at 12 weeks, This rise coincides with morphological changes in the uterine arteries that allow free flow of maternal blood into the placenta, and is associated with increases in the mRNA concentrations and activities of the antioxidant enzymes catalase, glutathione peroxidase, and manganese and copper/zinc superoxide dismutase within placental tissues. Between 8 to 9 weeks there is a sharp peak of expression of the inducible form of heat shock protein 70, formation of nitrotyrosine residues, and derangement of the mitochondrial cristae within the syncytiotrophoblast. We conclude that a burst of oxidative stress occurs in the normal placenta as the maternal circulation is established. We speculate that this may serve a physiological role in stimulating normal placental differentiation, but may also be a factor in the pathogenesis of pre-eclampsia and early pregnancy failure if antioxidant defenses are depleted.