TURNOVERS OF ERYTHROCYTES AND PLASMA PROTEINS IN MAMMALS
TURNOVERS OF ERYTHROCYTES AND PLASMA PROTEINS IN MAMMALS
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DOI：
10.1038/188037a0
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发表时间：
1960-01-01
期刊：
影响因子：
64.8
通讯作者：
ALLISON, AC
中科院分区：
文献类型：
--
作者：
ALLISON, AC
UCH的工作是研究不同动物的红细胞和血浆蛋白的存活情况。总的来说，已经出现了一个明确的模式。血浆蛋白从循环中以指数形式消失，如图1中的曲线A所示（参考文献1）。1、2）。在有利的碘化条件下，碘化蛋白质或被动转移的抗体球蛋白（包括所有年龄的蛋白质分子）的消失率与用 ** C-氨基酸标记后的蛋白质（其中大多数标记分子的年龄相似）的消失率相同，º。由此可见，血浆蛋白从循环中的排出是一个随机过程，在很大程度上与蛋白分子的年龄无关，这一过程与红细胞从循环中的排出形成鲜明对比。有大量证据表明，红细胞从循环中的正常消失是线性的，而不是指数的”（图1B）。通过将同位素甘氨酸掺入hæm标记的细胞显示图1C所示类型的存活曲线。除了最初的快速分解外，它们在一定时期内（人体内约100天）保持在近似恒定的水平，之后它们迅速从血液循环中消失”。".这表明，决定它们在循环中分解或从循环中去除的因素主要取决于老化细胞的某些性质，而外部因素是次要的
UCH work has been carried out on the survival of erythrocytes and plasma proteins in different animals. In general, a clear pattern has emerged. Plasma proteins disappear from the circulation exponentially, as illustrated by curve A in Fig. 1 (refs. 1, 2). Under favourable conditions of iodination, the rates of disappearance of iodinated proteins or passively transferred antibody globulins (including protein molecules of all ages) are the same as those obtained with proteins after** C-amino-acid labelling (in which most labelled molecules are of a similar age), º. It follows that removal of plasma pro-teins from the circulation is a random process which is largely independent of the age of the protein molecules.This process stands in sharp contrast to the removal of erythrocytes from the circulation. There is substantial evidence that the normal disappearance of erythrocytes from the circula-tion is linear rather than exponential"(Fig. 1B). Cells labelled by incorporation of isotopic glycine into hæm show survival curves of the type illustrated in Fig. 1C. Apart from an initial rapid breakdown, they remain at approximately constant level for a certain period, about 100 days in man, after which they rapidly disappear from the circulation".". This suggests that the factor determining their breakdown in or removal from the circulation depends primarily on some property of the aged cell, while external factors are of secondary