Effects of L3T4+ lymphocyte depletion on acute murine cytomegalovirus infection.
Effects of L3T4+ lymphocyte depletion on acute murine cytomegalovirus infection.
复制标题
L3T4 淋巴细胞耗竭对急性鼠巨细胞病毒感染的影响。
DOI：
10.1099/0022-1317-70-7-1765
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Shanley,JD
中科院分区：
文献类型：
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作者：
Erlich,KS;Mills,J;Shanley,JD
我们研究了携带L3T4表型的ofT淋巴细胞在急性小鼠巨细胞病毒（MCMV）感染中的作用。在急性MCMV感染期间，通过给药大鼠IgG2b单克隆抗体（MAb） GK 1.5来消耗小鼠的L3T4+淋巴细胞。与用盐水处理的对照组不同，接受单抗治疗的小鼠在唾液腺、肺和脾脏中出现了持续且高水平的病毒。MCMV抗体的产生被延迟，并且达到的滴度明显低于对照组。尽管病毒复制水平较高，但用单克隆抗体治疗的动物的死亡率没有增加。在MCMV腹腔内攻击后，L3T4+淋巴细胞的消耗具有保护作用，增加了产生死亡所需的MCMV剂量。这些数据表明，L3T4表型的T淋巴细胞影响急性感染期间MCMV复制的程度，并可能导致腹腔内病毒攻击后的死亡。
We examined the role ofT lymphocytes bearing the L3T4 phenotype in acute murine cytomegalovirus (MCMV) infection.In vivoadministration of rat IgG2b monoclonal antibody (MAb) GK 1.5 was used to deplete mice of L3T4+lymphocytes during acute MCMV infection. Unlike the saline-treated controls that resolved their infections, mice receiving the MAb developed persistent and high levels of virus in the salivary gland, lung and spleen. The production of antibody to MCMV was delayed and the titres achieved were markedly less than in the controls. Despite the higher levels of virus replication, there was no increase in mortality seen in animals treated with the MAb. Following intraperitoneal challenge with MCMV, depletion of L3T4+lymphocytes was protective, increasing the dose of MCMV required to produce death. These data indicate that T lymphocytes of the L3T4 phenotype influence the degree of MCMV replication during acute infection and may contribute to mortality following intraperitoneal virus challenge.