A Dense-Shell Macromolecular Scaffold for Catalyst- or Substrate-Guided Catalysis in a Cellular Environment
A Dense-Shell Macromolecular Scaffold for Catalyst- or Substrate-Guided Catalysis in a Cellular Environment
复制标题
用于细胞环境中催化剂或底物引导催化的密壳高分子支架
DOI：
10.1021/acsmaterialslett.9b00400
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发表时间：
2020-01-01
影响因子：
11.4
通讯作者：
Bai, Yugang
中科院分区：
文献类型：
--
作者：
Lu, Qing;Bai, Silei;Bai, Yugang
在大分子支架中放置金属配合物在提高合成目的和生物环境反应的催化活性方面显示出其有用性。在这里，我们证明了具有致密外壳和浓缩配体核的星型聚合物支架可以很容易地通过三-三唑配体直接介导的聚合-交联过程合成。简单的合成可以得到具有核-壳结构的聚合物纳米颗粒，具有致密的聚合物壳保护核中的配体，这些配体很容易用于金属配位。以铜和钯催化剂为例，研究了Cu和Pd大分子催化剂分别催化水相“咔嗒”反应和氨基甲酸丙酯脱保护。支架不仅可以保护和稳定催化中心，更重要的是，它们还可以调节以促进哺乳动物细胞中不同细胞位置的反应，并且产物的定位可以由催化支架或特殊设计的底物引导。
Placing metal complexes in macromolecular scaffolds has shown its usefulness in improving catalytic activity for synthetic purposes and reactions in biological environments. Here, we show that a star polymer scaffold with a dense shell and a concentrated ligand core can be readily synthesized from an integrated polymerization-crosslinking process mediated directly by a tris-triazole ligand. The straightforward synthesis can give well-defined polymeric nanoparticles with a core-shell structure, with a dense polymeric shell protecting the ligands in the core that are readily available for metal coordination. Using copper and palladium catalyst as examples, we show that those macro molecular Cu and Pd catalysts can mediate aqueous "click" reactions and propargyl carbamate deprotection, respectively. The scaffolds not only grant protection and stabilization of the catalytic centers, but, more importantly, they also can be tuned to promote reactions in different cellular locations in mammalian cells, and the localization of the products are guided by either the catalytic scaffold or specially designed substrates.