Aversive gustatory stimulation activates limbic circuits in humans.
Aversive gustatory stimulation activates limbic circuits in humans.
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DOI：
10.1093/brain/121.6.1143
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发表时间：
1998-06
期刊：
影响因子：
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通讯作者：
D. Zald;Joel T. Lee;Kevin W. Fluegel;J. Pardo
中科院分区：
文献类型：
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作者：
D. Zald;Joel T. Lee;Kevin W. Fluegel;J. Pardo
动物研究表明，杏仁核及其连接与厌恶性刺激的识别有关。最近的一项PET研究表明，人类杏仁核和左眶额皮质在接触厌恶性气味时显示局部脑血流量（rCBF）大幅增加。为了研究厌恶性味觉刺激是否同样激活这些区域，9名健康女性品尝了厌恶性盐水溶液，纯水和巧克力，同时用PET测量rCBF。与水条件相比，厌恶的生理盐水条件下，增加活动的右侧杏仁核，左前眶额皮质，内侧丘脑，前膝和背侧前扣带回，和右侧海马。当生理盐水与巧克力相比时，右侧杏仁核、左侧眶额皮质和前膝扣带回仍然显著激活。目前的研究结果表明，杏仁核和眶额皮质的反应，厌恶性刺激的嗅觉和味觉的方式，并强调的负性情绪处理中的作用，膝前扣带回。
Animal studies implicate the amygdala and its connections in the recognition of aversive stimuli. A recent PET study demonstrated that the human amygdala and left orbitofrontal cortex show substantial increases in regional cerebral blood flow (rCBF) during exposure to aversive odourants. To examine if aversive gustatory stimuli similarly activate these regions, nine healthy women tasted an aversive saline solution, pure water and chocolate while rCBF was measured with PET. The aversive saline condition, when contrasted with the water condition, increased activity in the right amygdala, left anterior orbitofrontal cortex, medial thalamus, pregenual and dorsal anterior cingulate, and the right hippocampus. The right amygdala, left orbitofrontal cortex and pregenual cingulate remained significantly activated when saline was compared with chocolate. The present results indicate that the amygdala and orbitofrontal cortex respond to aversive stimuli in both the olfactory and gustatory modalities, and highlight the role of the pregenual cingulate in negative emotional processing.