Cancer risk in waterpipe smokers: a meta-analysis
Cancer risk in waterpipe smokers: a meta-analysis
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DOI：
10.1007/s00038-016-0856-2
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发表时间：
2017-01-01
影响因子：
4.6
通讯作者：
Maisonneuve, Patrick
中科院分区：
文献类型：
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作者：
Mamtani, Ravinder;Cheema, Sohaila;Maisonneuve, Patrick
通过荟萃分析量化水烟与癌症（包括头颈癌、食道癌、胃癌、肺癌和膀胱癌）之间的关系，我们进行了系统的文献检索，以识别相关研究，对其质量进行评分，使用固定和随机效应模型估计汇总相对风险（SRR），评估异质性和出版偏倚。仅考虑高质量的研究，水烟与头颈癌（SRR 2.97; 95% CI 2.26-3.90）、食管癌（1.84; 1.42-2.38）和肺癌（2.22; 1.24-3.97）的风险增加相关，无异质性或发表偏倚的证据。胃癌和膀胱癌的风险也有所增加，但主要是基于低质量的研究。对于结直肠，肝脏和所有网站的综合风险估计值升高，但有足够的报告进行荟萃分析。相反的看法水管吸烟的相对安全性，这项荟萃分析提供了定量估计其与头颈部，食道和肺癌。现有报告的稀缺性和有限的质量表明，需要在明确定义的人群中进行更大规模的精心设计的研究。
To quantify by meta-analysis the relationship between waterpipe smoking and cancer, including cancer of the head and neck, esophagus, stomach, lung and bladder.We performed a systematic literature search to identify relevant studies, scored their quality, used fixed and random-effect models to estimate summary relative risks (SRR), evaluated heterogeneity and publication bias.We retrieved information from 28 published reports. Considering only highquality studies, waterpipe smoking was associated with increased risk of head and neck cancer (SRR 2.97; 95 % CI 2.26-3.90), esophageal cancer (1.84; 1.42-2.38) and lung cancer (2.22; 1.24-3.97), with no evidence of heterogeneity or publication bias. Increased risk was also observed for stomach and bladder cancer but based mainly on poor-quality studies. For colorectum, liver and for all sites combined risk estimates were elevated, but there were insufficient reports to perform a meta-analysis.Contrary to the perception of the relative safety of waterpipe smoking, this meta-analysis provides quantitative estimates of its association with cancers of the head and neck, esophagus and lung. The scarcity and limited quality of available reports point out the need for larger carefully designed studies in well-defined populations.