A new entry to carbocyclic nucleosides: Oxidative coupling reaction of cycloalkenylsilanes with a nucleobase mediated by hypervalent iodine reagent
A new entry to carbocyclic nucleosides: Oxidative coupling reaction of cycloalkenylsilanes with a nucleobase mediated by hypervalent iodine reagent
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DOI：
10.1021/ol8012155
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发表时间：
2008-08-21
期刊：
影响因子：
5.2
通讯作者：
Takahata, Hiroki
中科院分区：
文献类型：
--
作者：
Yoshimura, Yuichi;Ohta, Masatoshi;Takahata, Hiroki
提出了一种合成碳环核苷的新方法。新合成包括环烯基硅烷与硅基化核碱的直接偶联反应，由高价碘试剂催化。利用该方法，成功合成了以双（羟甲基）环己烯为假糖的新型碳环胞苷衍生物，作为潜在的抗hiv药物。
A novel method for synthesizing carbocyclic nucleosides was developed. The new synthesis includes a direct coupling reaction of cycloalkenylsilanes with a silylated nucleobase catalyzed by a hypervalent iodine reagent. By applying the method, a novel carbocyclic cytidine derivative having bis(hydroxymethyl)cyclohexene as a pseudosugar moiety, designed as a potential anti-HIV agent, was successfully synthesized.