Age-associated changes in neuromuscular transmission in the rat.
Age-associated changes in neuromuscular transmission in the rat.
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大鼠神经肌肉传递的年龄相关变化。
DOI：
10.1152/ajpcell.1984.247.3.c288
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
R. Cardaman
中科院分区：
文献类型：
--
作者：
D. Wilson;R. Cardaman
在1个月（28天）至1年（364天）的大鼠中，研究了神经肌肉传递与年龄相关的生理变化。采用细胞内记录技术监测大鼠膈肌神经接点的终板电位和微型终板电位。切断肌纤维可阻断肌肉动作电位。28日龄大鼠与42 ~ 364日龄大鼠相比，神经肌肉传递有显著差异。28天大的老鼠释放的量子较少。未成熟大鼠的统计存储量也明显小于老年组。然而，释放的统计概率与老年动物没有显着差异。对42 ~ 364天大鼠突触前参数的检查显示，量子释放没有显著增加。由此可见，大鼠的神经肌肉连接在6周龄时生理成熟，并在1岁时保持稳定。
The physiological changes in neuromuscular transmission associated with age were examined in rats between the ages of 1 mo (28 days) and 1 yr (364 days). Intracellular recording techniques were used to monitor end-plate potentials and miniature end-plate potentials at the rat diaphragm neuromuscular junction. Muscle action potentials were blocked by cutting the muscle fibers. Neuromuscular transmission was significantly different in 28-day-old rats compared with the older rats (42-364 days). The 28-day-old rats released fewer quanta. The statistical store in the immature rats was also significantly smaller than in the older age groups. The statistical probability of release, however, was not significantly different from the older animals. Examination of the presynaptic parameters in rats between the ages of 42 and 364 days revealed no significant increases in quantal release. It is concluded that the neuromuscular junction matures physiologically by 6 wk of age in rats and remains stable through the 1st yr of life.