Trichostatin A (TSA) facilitates formation of partner preference in male prairie voles (Microtus ochrogaster).
Trichostatin A (TSA) facilitates formation of partner preference in male prairie voles (Microtus ochrogaster).
复制标题
Trichostatin A（TSA）有助于雄性草原田鼠（Microtus ochrogaster）的伴侣偏好形成。
DOI：
10.1016/j.yhbeh.2016.04.001
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发表时间：
2016-05
影响因子：
3.5
通讯作者：
Kabbaj M
中科院分区：
文献类型：
--
作者：
Duclot F;Wang H;Youssef C;Liu Y;Wang Z;Kabbaj M
在社会一夫一妻制的草原田鼠（Microtus ochrogaster），社会纽带的发展是由伙伴偏好的形成，这涉及到各种环境和神经化学因素和大脑结构。在雌性草原田鼠的最新研究中，我们发现，组蛋白去乙酰化酶抑制剂曲古抑菌素A（TSA）的治疗，促进通过上调催产素受体（OTR）和加压素V1 a受体（V1 aR）基因表达的伴侣偏好的形成在NAcc（NAcc）。在本研究中，我们测试的假设，TSA治疗也有利于合作伙伴的偏好形成和改变OTR和V1 aR基因的表达在NAcc在雄性草原田鼠。因此，我们观察到，中央注射TSA剂量依赖性地促进形成的合作伙伴偏好在没有交配的雄性草原田鼠。有趣的是，TSA处理上调OTR，但不是V1 aR，基因表达在NAcc类似，因为它们受到交配-一个自然发生的伴侣偏好的必要过程。这些数据，与其他人一起，不仅表明参与的表观遗传事件，但也NAcc催产素在调节伴侣偏好的男性和女性草原田鼠的潜在作用。
In the socially monogamous prairie voles (Microtus ochrogaster), the development of a social bonding is indicated by the formation of partner preference, which involves a variety of environmental and neurochemical factors and brain structures. In a most recent study in female prairie voles, we found that treatment with the histone deacetylase inhibitor Trichostatin A (TSA) facilitates the formation of partner preference through up-regulation of oxytocin receptor (OTR) and vasopressin V1a receptor (V1aR) genes expression in the nucleus accumbens (NAcc). In the present study, we tested the hypothesis that TSA treatment also facilitates partner preference formation and alters OTR and V1aR genes expression in the NAcc in male prairie voles. We thus observed that central injection of TSA dose-dependently promoted the formation of partner preference in the absence of mating in male prairie voles. Interestingly, TSA treatment up-regulated OTR, but not V1aR, gene expression in the NAcc similarly as they were affected by mating – an essential process for naturally occurring partner preference. These data, together with others, not only indicate the involvement of epigenetic events but also the potential role of NAcc oxytocin in the regulation of partner preference in both male and female prairie voles.