Liver transplantation is associated with increased met‐enkephalin levels in the pig
Liver transplantation is associated with increased met‐enkephalin levels in the pig
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DOI：
10.1111/j.1399-6576.1996.tb05581.x
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发表时间：
1996-10
影响因子：
2.1
通讯作者：
K. L. Donovan;P. Janicki;W. T. Franks;V. I. Striepe-;C. Pinson
中科院分区：
文献类型：
--
作者：
K. L. Donovan;P. Janicki;W. T. Franks;V. I. Striepe-;C. Pinson
背景：有报道称肝移植术后吗啡的需要量少于胆囊切除术。这可能归因于内源性因素，而不是吗啡药代动力学的改变。在接受肝移植的猪和接受剖腹手术的对照组猪中，我们测量了两种与疼痛调节相关的内源性神经肽的血浆浓度，P物质（SP）和met -脑啡肽（ME）。
Background: It has been reported that less postoperative morphine is required following liver transplantation than is required following open cholecystectomy. This may be attributable to endogenous factors rather than to altered morphine pharmacokinetics. We measured the plasma concentrations of two endogenous neuropeptides associated with pain modulation, substance P (SP) and met‐enkephalin (ME), in pigs undergoing liver transplantation and in control pigs undergoing laparotomy.