Soluble endothelial cell selective adhesion molecule and cardiovascular outcomes in patients with stable coronary disease: A report from the Heart and Soul Study
Soluble endothelial cell selective adhesion molecule and cardiovascular outcomes in patients with stable coronary disease: A report from the Heart and Soul Study
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DOI：
10.1016/j.atherosclerosis.2015.10.092
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发表时间：
2015-12-01
期刊：
影响因子：
5.3
通讯作者：
Whooley, Mary
中科院分区：
文献类型：
--
作者：
Park, Meyeon;Kulkarni, Ameya;Whooley, Mary
背景和目标：内皮细胞选择性粘附分子（ESAM）选择性地表达于血管内皮，并被认为在动脉粥样硬化形成中起作用。我们调查了相关的血清可溶性ESAM（sESAM）水平与随后的心血管疾病的结果稳定性缺血性heartdisease.Methods：我们测量了sESAM水平在981例稳定性冠心病患者在2000年9月和2002年12月之间的前瞻性队列研究。Poisson回归模型被用来定义基线sESAM水平和心血管结局之间的关系，包括心肌梗死，心力衰竭住院治疗，和mortality.Results：有293个事件的复合终点超过中位数随访8.9年。在调整人口统计学和临床风险因素后，sESAM最高四分位数的参与者（与较低的三个sESAM四分位数相比）复合终点的发生率较高（事件率比率1.52（95% CI 1.16-1.99）及其单个组分：心肌梗死（IRR 1.64（1.06-2.55））、心力衰竭住院（IRR 1.96（1.32-2.81））和死亡（IRR 1.5（1.2-1.89））。这些协会已不再显着调整后估计肾小球滤过率。结论：sESAM水平与心肌梗死，心力衰竭，死亡调整后的人口和临床危险因素，但不调整后的肾功能。sESAM可能参与肾脏和心血管并发症的发病机制。(C)2015爱思唯尔爱尔兰有限公司版权所有。
Background and Aims: Endothelial cell-selective adhesion molecule (ESAM) is selectively expressed on vascular endothelium and is postulated to play a role in atherogenesis. We investigated the association of serum soluble ESAM (sESAM) levels with subsequent cardiovascular outcomes in patients with stable ischemic heart disease.Methods: We measured sESAM levels in 981 patients with stable coronary disease enrolled between September 2000 and December 2002 in a prospective cohort study. Poisson regression models were used to define the relationship between baseline sESAM levels and cardiovascular outcomes, including myocardial infarction, heart failure hospitalization, and mortality.Results: There were 293 occurrences of the composite endpoint over a median follow-up of 8.9 years. After adjusting for demographic and clinical risk factors, participants in the highest sESAM quartile (compared to the lower three sESAM quartiles) had a higher rate of the composite endpoint (incident rate ratio (IRR) 1.52 (95% CI 1.16-1.99) as well as of its individual components: myocardial infarction (IRR 1.64 (1.06-2.55)), heart failure hospitalizations (IRR 1.96 (1.32-2.81)), and death (IRR 1.5 (1.2-1.89)). These associations were no longer significant after adjustment for estimated glomerular filtration rate.Conclusions: sESAM levels associate with myocardial infarction, heart failure, and death after adjustment for demographic and clinical risk factors, but not after adjustment for kidney function. sESAM may be involved in the pathogenesis of concurrent kidney and cardiovascular disease. (C) 2015 Elsevier Ireland Ltd. All rights reserved.