Dietary changes favorably affect bone remodeling in older adults
Dietary changes favorably affect bone remodeling in older adults
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DOI：
10.1016/s0002-8223(99)00302-8
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发表时间：
1999-10-01
影响因子：
--
通讯作者：
Rosen, CJ
中科院分区：
文献类型：
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作者：
Heaney, RP;McCarron, DA;Rosen, CJ
目的探讨增加牛奶摄入量的饮食咨询是否能对钙经济产生有益的影响，以及是否可能产生其他与营养相关的改变。设计随机开放试验，研究对象为204名年龄在55岁至85岁之间的健康男性和女性，他们习惯于每天摄入少于1.5份乳制品。美国的六个学术健康中心。干预受试者被指示每天摄入3份脱脂牛奶或1%牛奶，作为他们日常饮食的一部分，或维持他们通常的饮食，在为期4周的基线观察之后的12周内。主要结果衡量从牛奶摄入量日志和3天食物记录评估的能量和营养摄入量；在基线和8周和12周时的血清促钙激素水平；结果补奶组钙摄入量增加729+/-45 mg/d(平均+/-标准差)，血清甲状旁腺激素水平下降约9%，骨吸收标志物N-端肽排泄量减少13%。补充牛奶的受试者尿钙排泄量增加了21+/-7.6毫克/天(平均+/-标准误差)，不到从钙摄入量增加中预计吸收的量的一半。所有这些变化只是与牛奶组的基线值和对照组的相应变化有显着差异。骨特异性碱性磷酸酶水平(骨形成标记物)在两组中都下降了约9%。牛奶组血清胰岛素样生长因子-1(IGF-1)水平升高10%(P
Objective To determine whether dietary counseling to increase milk intake could produce useful changes in the calcium economy and what, if any, other nutrition-related changes might be produced.Design Randomized, open trial.Subjects/setting Two hundred four healthy men and women, aged 55 to 85 years, who habitually consumed fewer than 1.5 servings of dairy foods per day. Six academic health centers in the United States.Intervention Subjects were instructed to consume 3 servings per day of nonfat milk or 1% milk as a part of their daily diets, or to maintain their usual diets, for a 12-week intervention period, which followed 4 weeks of baseline observations.Main outcome measures Energy and nutrient intake assessed from milk intake logs and 3-day food records; serum calciotrophic hormone levels at baseline and at 8 and 12 weeks; urinary excretion of calcium and N-telopeptide at 12 weeks.Statistical analyses Repeated-measures analysis of variance.Results In the milk-supplemented group, calcium intake increased by 729+/-45 mg/day (mean+/-standard error), serum parathyroid hormone level decreased by approximately 9%, and urinary excretion of N-telopeptide, a bone resorption marker, decreased by 13%. Urine calcium excretion increased in milk-supplemented subjects by 21+/-7.6 mg/day (mean+/-standard error), less than half the amount predicted to be absorbed from the increment in calcium intake. AU of these changes mere significantly different from baseline values in the milk:group and from the corresponding changes in the control group. Bone-specific alkaline phosphatase level (a bone formation marker) fell by approximately 9% in both groups. Serum level of insulin-like growth factor-1 (IGF-1) rose by 10% in the milk group (P