International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.
International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.
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DOI：
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发表时间：
2001-03
影响因子：
21.1
通讯作者：
B. Khakh;G. Burnstock;C. Kennedy;B. King;R. North;P. Séguéla;M. Voigt;P. Humphrey
中科院分区：
文献类型：
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作者：
B. Khakh;G. Burnstock;C. Kennedy;B. King;R. North;P. Séguéla;M. Voigt;P. Humphrey
ATP作为体液介质在细胞外控制细胞功能。介导ATP作用的受体属于两类，即代谢型P2Y受体和递质门控离子通道P2X受体。本文综述了P2X受体的结构、分布、功能和配体识别特性。P2X受体由7个不同的亚基组成，它们既可以作为同源聚合物，也可以作为异源聚合物。P2X受体的药理学由于物种直系同源物之间的显著差异而变得复杂。目前的命名法主要是基于重组受体的研究和内源性P2X受体在天然组织中的详细知识是有限的，因为缺乏良好的选择性激动剂和拮抗剂的每种受体类型。
ATP acts as a humoral mediator to control cell function extracellularly. The receptors that mediate the actions of ATP belong to two classes, the metabotropic P2Y receptors and the transmitter-gated, ion channel P2X receptors. This review describes the structure, distribution, function, and ligand recognition characteristics of P2X receptors, which comprise seven distinct subunits that can function as both homo- and hetero- polymers. The pharmacology of P2X receptors is complicated by marked differences between species orthologues. The current nomenclature is based largely on recombinant receptor studies and detailed knowledge of endogenous P2X receptors in native tissues is limited because of lack of good selective agonists and antagonists for each receptor type.