Effect of exclusive cigarette smoking and in combination with waterpipe smoking on lipoproteins
Effect of exclusive cigarette smoking and in combination with waterpipe smoking on lipoproteins
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DOI：
10.1016/j.jegh.2017.08.006
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发表时间：
2017-12-01
影响因子：
7.3
通讯作者：
Salameh, Pascale
中科院分区：
文献类型：
--
作者：
Hallit, Souheil;Zoghbi, Marouan;Salameh, Pascale
目的：与非烟草使用者相比，烟草使用者的总胆固醇和LDL-C显着增加。水烟和吸烟对LDL水平的叠加效应尚未研究。该研究的目的是评估吸烟与黎巴嫩吸烟者的LDL水平之间的相关性，并检查水烟和吸烟对LDL水平的相互作用。方法：这项横断面研究于2016年10月至2017年2月在4个不同的实验室进行，招募了308名患者（188名非吸烟者，105名吸烟者，15名既往吸烟者）。（β = 25.57; p < 0.0001）与高LDL水平和高总胆固醇水平显著相关（β = 53.29; p < 0.0001）。在目前吸烟且目前吸烟且吸烟者中，相对于目前吸烟且不吸烟者，观察到LDL水平显着增加（Beta = 66.64 vs Beta = 37.37; p < 0.0001）。结论：在黎巴嫩目前吸烟者中，LDL水平相对于不吸烟者增加，与其他人群的发现一致。此外，在黎巴嫩目前的吸烟者中，目前的水管吸烟可能会增加与不良冠状动脉效应相关的不良血脂水平，超过单独吸烟。在我们的研究中，导致这些观察到的变化的直接原因尚未确定，希望未来的研究能够揭示它。（C）2017年沙特阿拉伯卫生部。由爱思唯尔有限公司发布
Objective: A significant increase in total cholesterol and LDL-C is well shown in tobacco users, as compared to non-tobacco users. The additive effects of waterpipe and cigarette smoking on LDL levels have not been studied. The study's objective was to assess the correlation between cigarette smoking and LDL levels in Lebanese cigarette smokers and to check the interaction effect of waterpipe and cigarette smoking on LDL levels.Methods: This cross-sectional study was conducted between October 2016 and February 2017 in 4 different laboratories, enrolling 308 patients (188 non-smokers, 105 cigarette smokers, 15 previous smokers).Results: Current cigarette smoking (Beta = 25.57; p < 0.0001) was significantly associated with higher LDL levels and higher total cholesterol levels (Beta = 53.29; p < 0.0001) in exclusive cigarette smokers. Among current cigarette smokers who were current waterpipe smokers, a significant increase in LDL level was observed relative to current cigarette smokers who were not waterpipe smokers (Beta = 66.64 vs Beta = 37.37; p < 0.0001).Conclusion: Among Lebanese current cigarette smokers, LDL levels increased relative to nonsmokers, consistent with findings in other populations. In addition, among Lebanese current cigarette smokers, current waterpipe smoking might increase adverse lipid profiles associated with adverse coronary effects more than cigarette smoking alone. The direct cause responsible for these observed variations in our study remains unidentified, with the hope that future research will reveal it. (C) 2017 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd.